Results 131 to 140 of about 14,994 (162)
Some of the next articles are maybe not open access.
3. TOXICITY OF PRIMAQUINE IN CAUCASIANS
JAMA: The Journal of the American Medical Association, 1952Primaquine, 8-(4-amino-1-methylbutylamino)-6-methoxyquinoline,1a new curative agent for vivax malaria, has recently been extensively tested in the Armed Forces. Since mid-December, 1951, veterans returning from Korea have received 15 mg. of primaquine base once daily for two weeks aboard Military Sea Transport ships after termination of weekly ...
Robert S. Hockwald +5 more
openaire +3 more sources
Chemischer Informationsdienst, 1977
Various 5-phenoxy derivatives of primaquine have been prepared which are more active and less toxic than the parent compound in murine and monkey antimalarial screens. An improved method for the phthalimido alkylation of amines is described.
Edward A. Nodiff +4 more
openaire +4 more sources
Various 5-phenoxy derivatives of primaquine have been prepared which are more active and less toxic than the parent compound in murine and monkey antimalarial screens. An improved method for the phthalimido alkylation of amines is described.
Edward A. Nodiff +4 more
openaire +4 more sources
Modifications of primaquine as antimalarials. 4. 5-Alkoxy derivatives of primaquine
Journal of Medicinal Chemistry, 1987Thirty-two 5-alkoxyprimaquines have been synthesized and evaluated as blood schizonticides (Plasmodium berghei, mouse) and tissue schizonticides (Plasmodium cynomolgi, monkey). Several of these compounds were extremely active in both screens. Such a broad spectrum of antimalarial efficacy offers the possibility of a single drug that could cure the ...
E H, Chen +3 more
openaire +2 more sources
The hemolytic effect of primaquine. III. A study of primaquine-sensitive erythrocytes.
The Journal of laboratory and clinical medicine, 1954Abstract The erythrocytes of primaquine-sensitive and nonsensitive individuals not receiving primaquine have been compared in the following respects: (a) morphology; (b) antigenic characteristics; (c) sensitivity to acid hemolysis; (d) hemoglobin type; (e) mechanical, osmotic, and chemical fragility; (f) the fragility to the in vitro hemolytic action ...
Ernest Beutler +2 more
openaire +2 more sources
Annals of Internal Medicine, 1980
Excerpt To the editor: I wish to report an unusual reaction to primaquine therapy. A 55-year-old man with malaria was treated with chloroquine, and when chloroquine therapy was finished primaquine ...
openaire +2 more sources
Excerpt To the editor: I wish to report an unusual reaction to primaquine therapy. A 55-year-old man with malaria was treated with chloroquine, and when chloroquine therapy was finished primaquine ...
openaire +2 more sources
The American Journal of Tropical Medicine and Hygiene, 1990
The antimalarial activities of primaquine and its metabolites against exoerythrocytic (EE) stages of Plasmodium berghei in vitro were compared with their abilities to spontaneously generate activated oxygen. A quantitative relationship between the number of sporozoites and the number of EE merozoites produced was established.
Michael R. Hollingdale +4 more
openaire +3 more sources
The antimalarial activities of primaquine and its metabolites against exoerythrocytic (EE) stages of Plasmodium berghei in vitro were compared with their abilities to spontaneously generate activated oxygen. A quantitative relationship between the number of sporozoites and the number of EE merozoites produced was established.
Michael R. Hollingdale +4 more
openaire +3 more sources
Primaquine Sensitivity of Erythrocytes
Archives of Internal Medicine, 1961The recent surge of interest in genetics has been associated with the remarkable development of biochemical techniques. These methods have enabled us to comprehend the action of the genes in terms of their relationship to protein specificity and ultimately of their control over rates of metabolic reactions.
openaire +3 more sources
Primaquine Resistance in Plasmodium vivax
The American Journal of Tropical Medicine and Hygiene, 1996Reports have appeared calling attention to what has been termed primaquine resistance in Plasmodium vivax in several geographic areas. The possibility exists that primaquine tolerant strains (often referred to as the tropical zone type from the South Pacific and Southeast Asian regions characterized by early and frequent relapses) may have become ...
Geoffrey M. Jeffery, William E. Collins
openaire +3 more sources
Tissue Distribution of Primaquine in the Rat
Pharmacology, 1981The distribution of primaquine was measured in seven rat tissues at 15-180 min after the intraperitoneal injection of the antimalarial 8-aminoquinoline. The half-life of unmetabolized primaquine was 4.0 h in lung, 1.7-1.9 h in blood, spleen, kidney and heart, and 1.2 h in liver.
James B. Griffin +3 more
openaire +3 more sources
An Unusual Reaction to Chloroquine-Primaquine
JAMA: The Journal of the American Medical Association, 1976TWO DAYS after taking one chloroquine phosphate (300-mg base)-primaquine phosphate (45-mg base) malaria prophylaxis tablet, a woman noted that her urine was red. Without a history of prophyria cutanea tarda, the patient's symptoms and red urine might readily be attributed to primaquine-induced hemolysis in a glucose 6-phosphate-dehydrogenase-deficient ...
Benjamin A. Guider +2 more
openaire +3 more sources