Results 111 to 120 of about 3,657 (146)

Antimalarial drug-primaquine and reduced glutathione (GSH)

, 1998
107-108The effects of antimalarial drug, primaquine, on the status of erythrocyte reduced glutathione (GSH) and glutathione reductase (GR) activity in albino rats (Charles foster) are investigated. GSH levels and GR activity in primaquine treated rats
Suhail, Mohammad, Ahmad, Imtiaz
core  

Primaquine revisited six decades after its discovery [PDF]

European Journal of Medicinal Chemistry, 2009
Primaquine was firstly synthesized in 1946 in the USA, and is the most representative member of the anti-malarial 8-aminoquinolines. Six decades have passed and primaquine is still the only transmission-blocking anti-malarial clinically available ...
Nuno Vale, P Gomes, R Moreira
exaly   +2 more sources

Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children [PDF]

Antimicrobial Agents and Chemotherapy, 2017
Low-dose primaquine is recommended to prevent Plasmodium falciparum malaria transmission in areas threatened by artemisinin resistance and areas aiming for malaria elimination.
Bronner Gonçalves, Rob Ter Heine, Teun Bousema   +2 more
exaly   +3 more sources

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Primaquine

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The conversion of primaquine into primaquine-aldehyde, primaquine-alcohol, and carboxyprimaquine, a major plasma metabolite.

The Journal of laboratory and clinical medicine, 1991
Although efficacy and toxicity of primaquine (PQ) depend on bioconversion, the process is poorly understood, even for carboxyprimaquine (CPQ), the major plasma metabolite. Earlier work to clarify drug metabolism showed that PQ could be converted quantitatively into CPQ, in vitro, with human erythroleukemic K562 cells or nonleukemic bone marrow ...
H, Frischer, R L, Mellovitz, T, Ahmad, M V, Nora   +3 more
openaire   +1 more source

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Population Pharmacokinetics of Primaquine in the Korean Population

Pharmaceutics, 2021
Joon-Sup Yeom, Choon Ok Kim, Kyungsoo Park   +2 more
exaly  

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