Results 101 to 110 of about 4,961,010 (265)

Screening Rates for Primary Aldosteronism in Resistant Hypertension

HYPERTENSION, 2020
Resistant hypertension is associated with higher rates of cardiovascular disease, kidney disease, and death than primary hypertension. Although clinical practice guidelines recommend screening for primary aldosteronism among persons with resistant ...
G. Jaffe, Zachary Gray, G. Krishnan, M. Stedman, Yuanchao Zheng, Jialin Han, G. Chertow, J. Leppert, Vivek Bhalla   +8 more
semanticscholar   +1 more source

Trained Immunity and Cardiovascular Risk: An Immunological Perspective

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Systemic inflammation is a key driver of atherogenesis and its complications. While anti‐inflammatory therapies targeting pathways such as IL‐1β and IL‐6 have shown promise in established atherosclerotic cardiovascular disease (ASCVD), potential systemic effects raise concerns about immune suppression and infection, underscoring the need for ...
Katherine A. Boden, Jason Chai, Tafadzwa T. J. Kufazvinei, Robin P. Choudhury   +3 more
wiley   +1 more source

Correction: Spironolactone reduces biochemical markers of bone turnover in postmenopausal women with primary aldosteronism [PDF]

, 2021
Christian Adolf, Leah Braun, Carmina Teresa Fuß, Stefanie Hahner, Heike Künzel, Laura Handgriff, Lisa Sturm, Daniel Heinrich, Holger Schneider, Martin Bidlingmaier, Martín Reincke   +10 more
openalex   +1 more source

Clinical Trial: Efficacy and Safety of Velusetrag in Chronic Intestinal Pseudo‐Obstruction: A Randomized, Phase 2, Placebo‐Controlled, Crossover, Multiple (n = 1), Proof‐of‐Concept Study

Neurogastroenterology &Motility, Volume 38, Issue 1, January 2026.
This phase 2 proof‐of‐concept trial evaluated the efficacy and safety of velusetrag in patients with chronic intestinal pseudo‐obstruction. Velusetrag treatment was generally well tolerated and was associated with improved symptoms and a reduction in pseudo‐obstructive episodes versus placebo, although these differences did not reach statistical ...
Carolina Malagelada, Roberto De Giorgio, Rosanna Francesca Cogliandro, Luis Alcalá‐González, Anna Costanzini, Valeria Scuderi, Sara Manzoni, Elena Pasquali, Jan Tack, Vincenzo Stanghellini   +9 more
wiley   +1 more source

Clinical significance of parathyroid hormone in mineral and glucose metabolism disorders among patients with primary aldosteronism

SAGE Open Medicine
Objective: To investigate the differences in mineral and glucose metabolic disorders among patients with primary aldosteronism, nonfunctional adrenal tumors, and controls. Methods: A retrospective analysis was conducted on clinical data from 578 patients,
Zhilian Sun, Wenxiu Liu
doaj   +1 more source

Acid‐sensing ion channel 1a deficiency drives endocrine hypertension in male mice

The Journal of Physiology, Volume 604, Issue 1, Page 172-192, 1 January 2026.
Abstract figure legend Acid‐sensing ion channel 1a deficiency drives endocrine hypertension in aged male mice. Global deletion of ASIC1a (Asic1a−/−) in adult male mice (6 months old) elevates corticosterone, leading to hypokalaemia, volume expansion, increased pulse pressure and cardiomyocyte hypertrophy.
Selina M. Garcia, Megan N. Tuineau, Xavier A. DeLeon, Neil D. Detweiler, Shristey Tamang, Nancy L. Kanagy, Laura V. Gonzalez Bosc, Thomas C. Resta, Jay S. Naik, Nikki L. Jernigan   +9 more
wiley   +1 more source

Computed Tomography Angiography‐Assisted Ovarian Vein Sampling for Diagnosing an Androgen‐Producing Leydig Cell Tumor: A Case Report

Case Reports in Endocrinology, Volume 2026, Issue 1, 2026.
Background Ovarian Leydig cell tumors, rare androgen‐producing neoplasms, may present with rapidly progressive virilization. Preoperative localization is frequently challenging, particularly when bilateral ovarian abnormalities coexist or radiologic findings are equivocal.
Ken Tomotsune, Daisuke Saito, Satoshi Saitou, Yusuke Seki, Souta Hayashi, Yumiko Yamashita, Maiko Takata, Kentarou Ohara, Yohei Masugi, Yutaka Saito, Koki Kato, Tomotoshi Hosokawa, Osamu Isozaki   +12 more
wiley   +1 more source

Targeting Cryptochromes in Chronic Diseases

Cell Biology International, Volume 49, Issue 12, Page 1579-1590, December 2025.
ABSTRACT The circadian clock generates 24‐h molecular rhythms through transcription–translation negative feedback loops (TTFLs) and regulates daily physiological processes such as sleep–wake cycles, body temperature, hormone secretion, metabolism, and immune function.
Takuro Toda, Tsuyoshi Hirota
wiley   +1 more source

Diagnostic Challenges of Adrenal Venous Sampling for Primary Hyperaldosteronism in a Patient With Subclinical Cushing's Syndrome: A Case Report

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Hypertension is a significant comorbidity in the New World, and its prevalence is rising. Around 5%–10% of cases with hypertension have secondary hypertension. Adrenal gland disease is among the common causes of secondary hypertension. We present a 57‐year‐old male with uncontrolled hypertension and a history of intracranial hemorrhage.
Mahsa Malekian, Vahide Sadra, Amir Bahrami, Javad Jalili, Hamidreza Ashayeri   +4 more
wiley   +1 more source

Diagnostic uncertainty in primary aldosteronism [PDF]

Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor"
Aldosterone is a mineralocorticoid hormone originating from the glomerulosa zone of the adrenal cortex. Its main mechanism of action involves the reabsorption of sodium along with the secretion of potassium and hydrogen ions.
Marković Bojan, Stojković Mirjana, Janić Tamara, Babić Jovana, Đurković Ivana, Joksimović Nata, Nedeljković-Beleslin Biljana, Ćirić Jasmina, Žarković Miloš   +8 more
doaj   +1 more source