Results 71 to 80 of about 4,506,322 (141)

In silico Analysis of Natural Iridoids as Primary Amoebic Meningoencephalitis Inhibitors: Molecular Docking, MD Simulation, MMPBSA, and DFT Analyses [PDF]

Iridoids have demonstrated various activities, including anti-inflammatory, anticancer, cardioprotective, antiviral, hepatoprotective, antihyperglycemic, and antiparasitic effects.
Saha, Supriyo, Prinsa
core   +1 more source

The anti-amoebic potential of carboxamide derivatives containing sulfonyl or sulfamoyl moieties against brain-eating Naegleria fowleri

, 2023
Naegleria fowleri is a free-living thermophilic flagellate amoeba that causes a rare but life-threatening infection called primary amoebic meningoencephalitis (PAM), with a very high fatality rate.
Alawfi, Bader S., Seyed-Omar Zaraei, Bader S. Alawfi, Ruqaiyyah Siddiqui, Zaraei, Seyed-Omar, Khan, Naveed Ahmed, Akbar, Noor, El-Gamal, Mohammed I., Noor Akbar, Mohammed I. El-Gamal, Naveed Ahmed Khan, Siddiqui, Ruqaiyyah   +11 more
core   +1 more source

Comparative neuropathology of Balamuthia mandrillaris infection across species

Parasitology
Balamuthia mandrillaris is a free-living amoeba that causes granulomatous amoebic encephalitis, a rare but frequently fatal infection of the central nervous system.
Ruqaiyyah Siddiqui, Sutherland Maciver, David Lloyd, Naveed Ahmed Khan   +3 more
doaj   +1 more source

Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism [PDF]

, 2005
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous ...
S. Jayasekera, N. A. Khan, M. Stins, K. S. Kim, Alsam, S., Stins, M., Khan, Naveed Ahmed, Sissons, J., J. Sissons, Kim, K.S., Jayasekera, S., S. Alsam   +11 more
core   +1 more source

Recurring seasonal cases of Naegleria fowleri (Brain‐Eating Amoeba) in Pakistan: A rapidly growing threat

Health Science Reports, Volume 7, Issue 7, July 2024.
Rana Uzair Ahmad, Muhammad Arslan Bilal, Muhammad Fawad Ashraf, Safi Ur Rehman Daim, Malik Olatunde Oduoye, Inibehe Ime Okon   +5 more
wiley   +1 more source

Chemotherapeutic and Disinfection Strategies

, 2016
While it is fortunate that primary amoebic meningoencephalitis is a rare disease, its rarity makes rigorous studies to find the most effective treatment difficult.
Ali, Ibne Karim M., Khan, Naveed Ahmed, Cope, Jennifer R., Siddiqui, Ruqaiyyah   +3 more
core   +1 more source

A review of the mechanism, diagnosis, and treatment of Naegleria fowleri infection

Frontiers in Microbiology
Naegleria fowleri is a rare pathogen responsible for primary amoebic meningoencephalitis (PAM), a fatal central nervous system infection characterized by rapid clinical progression and an extremely high mortality rate. The existing diagnostic methods are
Ling Dai, Xin-Ru Guo, Xu-Rui Chen, Ming-Hao Ma, Zi-Han Liu, Juan Lai, Jun Lu, Ming Feng, Xi-Xia Liu, Sheng-Hui Yang   +9 more
doaj   +1 more source

Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae.

PLoS Neglected Tropical Diseases, 2020
Diseases caused by pathogenic free-living amoebae include primary amoebic meningoencephalitis (Naegleria fowleri), granulomatous amoebic encephalitis (Acanthamoeba spp.), Acanthamoeba keratitis, and Balamuthia amoebic encephalitis (Balamuthia ...
Christopher A Rice, Beatrice L Colon, Emily Chen, Mitchell V Hull, Dennis E Kyle   +4 more
doaj   +1 more source

The Mitochondrial Genome and a 60‐kb Nuclear DNA Segment from Naegleria fowleri, the Causative Agent of Primary Amoebic Meningoencephalitis [PDF]

, 2013
Naegleria fowleri is a unicellular eukaryote causing primary amoebic meningoencephalitis, a neuropathic disease killing 99% of those infected, usually within 7-14 days. Naegleria fowleri is found globally in regions including the US and Australia.
Greninger, Alexander L, Chiu, Charles Y, Marciano‐Cabral, Francine, Herman, Emily K, Dacks, Joel B, Visvesvara, Govinda S   +5 more
core   +1 more source

Integrated track of nano-informatics coupling with the enrichment concept in developing a novel nanoparticle targeting ERK protein in Naegleria fowleri

Open Chemistry
Naegleria fowleri is a free-living amoeba that causes primary amoebic meningoencephalitis. Despite combination drug therapies, N. fowleri is not sensitive to current drug therapies, contributing to the pathogen’s mortality rate of 98%. To enable rational
Naveed Muhammad, ul Ain Noor, Aziz Tariq, Saleem Ayesha, Shabbir Muhammad Aqib, Khan Ayaz Ali, Albekairi Thamer H.   +6 more
doaj   +1 more source