Results 61 to 70 of about 4,506,322 (141)

Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, DFT Calculations, and In Vitro Validation

Cancer Reports, Volume 8, Issue 8, August 2025.
ABSTRACT Background The PI3K/Akt/mTOR signaling pathway is commonly deregulated in different types of cancers, contributing to tumor proliferation, persistence, and resistance to treatment. Akt1, a crucial kinase within this pathway, plays a critical role in tumor progression and the occurrence of therapeutic resistance.
Shokoofeh Jamshidi, Ali Eghbalian, Setareh Shojaei, Amir Taherkhani, Mehran Feizi‐Dehnayebi   +4 more
wiley   +1 more source

Drugs used for the treatment of cerebral and disseminated infections caused by free‐living amoebae

Clinical and Translational Science, 2021
Free‐living amoebae (FLAs) are protozoa developing autonomously in diverse natural or artificial environments. The FLAs Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri represent a risk for human health as they can become pathogenic and ...
Alexandre Taravaud, Zineb Fechtali‐Moute, Philippe M. Loiseau, Sébastien Pomel   +3 more
doaj   +1 more source

ISEV2023 Abstract Book

, 2023
Journal of Extracellular Vesicles, Volume 12, Issue S1, May 2023.
wiley   +1 more source

Isolation of Naegleria lustrarea n. sp. (Excavata, Discoba, Heterolobosea) from the feces of Ambystoma annulatum (Ringed Salamander) in Northwest Arkansas

Journal of Eukaryotic Microbiology, Volume 71, Issue 4, July/August 2024.
Abstract The salamander, Ambystoma annulatum, is considered a “species of special concern” in the state of Arkansas, USA, due to its limited geographic range, specialized habitat requirements and low population size. Although metazoan parasites have been documented in this salamander species, neither its native protists nor microbiome have yet been ...
Brian M. Becker, Idan Banson, James M. Walker, Anant Deshwal, Matthew W. Brown, Jeffery D. Silberman   +5 more
wiley   +1 more source

Late Breaking Orals

, 2022
Journal of Extracellular Vesicles, Volume 11, Issue S2, August 2022.
wiley   +1 more source

Primary Amoebic Meningoencephalitis: Neurochemotaxis and Neurotropic Preferences of Naegleria fowleri.

, 2016
Naegleria fowleri causes one of the most devastating necrotic meningoencephalitis in humans. The infection caused by this free-living amoeba is universally fatal within a week of onset of the signs and symptoms of the disease called primary amoebic ...
Abdul Mannan Baig, Baig, Abdul Mannan, Dr.   +1 more
core   +1 more source

Occurrence of small free-living amoebae from natural water resources

Environment Conservation Journal, 2009
Small  free-living amoebae are also  called  as amphizoic amoebae,  because of their capability to exist both  as free-living  as well  as opportunistically  pathogenic.
Tabrez Ahmad, Newton Paul, A. K. Sharma
doaj   +1 more source

Glucose metabolism in the pathogenic free‐living amoebae: Tempting targets for treatment development

Chemical Biology &Drug Design, Volume 103, Issue 1, January 2024.
Enzymes involved in glucose metabolism may be promising therapeutic targets for drug development against the pathogenic free‐living amoebae. Details about the enzyme sequence and structural properties make a compelling case for designing small molecule inhibitors that are specific to the amoebae and would not affect the host enzyme.AbstractPathogenic ...
Jillian E. Milanes, Samuel Kwain, Allyson Drawdy, Laura Dodson, Matthew T. Monaghan, Christopher A. Rice, Brian N. Dominy, Daniel C. Whitehead, James C. Morris   +8 more
wiley   +1 more source

Case Report Primary Amoebic Meningoencephalitis in an Infant due to Naegleria fowleri

, 2020
Primary amoebic meningoencephalitis (PAM) caused by free-living amebae Naegleria fowleri is a rare and fatal condition. A fatal case of primary amoebic meningoencephalitis was diagnosed in a 5-month-old infant who presented with the history of decrease ...
Vinay Khanna, Ruchee Khanna, V Shashidhar, Karthick Annamalai, C.-C Huang, Deepak Nayak, Sunil Mundkar, Frenil Munim, Chiranjay Mukhopadhayay, A Fasano, Shrikiran Hebbar, J L González-Gutiérrez, J Lazareff   +12 more
core  

Detection and Confirmation of Naegleria fowleri in a Primary Amebic Meningoencephalitis Patient Using a Molecular Approach

Journal of Parasitology Research, Volume 2024, Issue 1, 2024.
The Naegleria fowleri amoeba stands as the primary culprit behind primary amebic meningoencephalitis (PAM), presenting a substantial global public health concern. In recent years, over 17 cases of PAM have been reported in Karachi, Pakistan, highlighting its increased prevalence in the country’s most densely populated city.
Muhammad Aurongzeb, Muhammad Amer Nazir, Raheela Yasmin, Ammeema Kiran, Raiha Fatima, Rehan Ali, Salman Ahmed Khan, Asad Ul-Haq, Khalid Al-Regaiey, Turki Abualait, Imdad Kaleem, Shahid Bashir, Bernard Marchand   +12 more
wiley   +1 more source