Results 121 to 130 of about 4,431,933 (293)
Farnesoid X Receptor Agonists: A Promising Therapeutic Strategy for Gastrointestinal Diseases
Gastro Hep AdvancesFarnesoid X receptor (FXR) agonists have emerged as a promising therapeutic strategy for the management of various gastrointestinal (GI) diseases, including primary biliary cholangitis, nonalcoholic fatty liver disease, inflammatory bowel disease ...
Mohammad Almeqdadi, Fredric D. Gordon
doaj +1 more source
Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis, and Autoimmune Hepatitis
, 2019 Autoimmune liver diseases (AILDs), comprising primary biliary cirrhosis (PBC; also referred to as primary biliary cholangitis), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH), are complex conditions in which both genetic and ...
Martín, J. +5 more
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Primary sclerosing cholangitis: a pre-malignant condition [PDF]
, 2017 Primary sclerosing cholangitis (PSC) is a chronic, progressive, cholestatic liver disease with no known cure. It is a serious condition, and diagnosis comes with an increased risk of developing cancer of the gallbladder, bile ducts or liver.
Gerri Mortimore, Mortimore, Gerri
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Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics
Mass Spectrometry Reviews, EarlyView.ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers +5 more
wiley +1 more source
A Rare Case of Concurrent Primary Biliary Cholangitis and Sarcoidosis
Primary biliary cholangitis and sarcoidosis are the two most common causes of granulomatous liver disease in the US; however, their expected clinical course and management are starkly different. This case involves a patient with granulomas noted on liver
Bandaru, Mrudula +4 more
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Movement Disorders, EarlyView.Abstract Background Ursodeoxycholic acid (UDCA) has shown mitochondrial and neuroprotective effects and has been proposed as a treatment for Parkinson's disease (PD). However, population‐level evidence on its effect on PD risk is lacking. Objectives To compare the risk of incident PD among UDCA initiators versus matched non‐initiators within a ...
Chengsheng Ju +7 more
wiley +1 more source
Imaging of Benign Biliary Tract Disease
Indian Journal of Radiology and ImagingThis review article discusses the most common benign biliary disorders and the various radiological findings on multiple modalities. A broad spectrum of diseases including various congenital disorders, infective and parasitic etiologies, immunological ...
Samarjit Singh Ghuman +5 more
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Primary sclerosing cholangitis: diagnostic and management challenges
, 2017 Sanjeev Sirpal,1 Natasha Chandok2 1Department of Medicine, Centre Hospitalier de l’Université de Montréal (CHUM), University of Montreal, Montreal, QC, 2Department of Medicine, University of Western Ontario, London, ON, Canada ...
Sirpal S, Chandok N
core
The Journal of Pathology, EarlyView.Abstract Ductular reactions (DRs) are dynamic and complex multicellular responses that occur as a result of various hepatic injuries. Precise identification and quantification of the extent of DRs is a cornerstone of pre‐clinical modelling of liver disease, with links to inflammation, fibrosis, regeneration, and disease severity.
Nathalie Feeley +15 more
wiley +1 more source