Results 121 to 130 of about 48,035 (283)

Antibiotic treatment for 1 day versus 4–7 days in patients with acute cholangitis after adequate endoscopic biliary drainage (COBRA): study protocol for a randomized controlled trial

Trials
Background Acute cholangitis is an infection of the biliary tract that is managed with adequate biliary drainage combined with antibiotic treatment. The international Tokyo Guidelines 2018 recommend 4 to 7 days of antibiotic treatment after adequate ...
Anouk G. Overdevest, Elske Sieswerda, Sylke Haal, Johannes A. Bogaards, Martine A. M. C. Baven – Pronk, Auke Bogte, Karam S. Boparai, Frank ter Borg, Menno A. Brink, Foke van Delft, Vincent K. Dik, Paul Fockens, Lennard P. L. Gilissen, Muhammed Hadithi, Wouter L. Hazen, Frans van der Heide, Wouter J. den Hollander, Akin Inderson, Pieter Jan F. de Jonge, Sjoerd D. Kuiken, J. Marius Munneke, Lars E. Perk, Alexander C. Poen, Jan-Werner Poley, Rutger Quispel, Robert C. H. Scheffer, Dirk W. Schölvinck, Ellert J. van Soest, Adriaan C. I. T. L. Tan, Willem J. Thijs, Niels G. Venneman, Robert C. Verdonk, Wim van de Vrie, Jan Maarten Vrolijk, Roy L. J. van Wanrooij, Pim W. Weijenborg, Marcel G. W. Dijkgraaf, Jan M. Prins, Rogier P. Voermans   +38 more
doaj   +1 more source

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source

When Enzymes Mislead: Assessing the Value of MRCP in Suspected Choledocholithiasis

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background The diagnosis of choledocholithiasis (CDL) requires balancing timely intervention against the risks of unnecessary invasive procedures. Although liver function tests (LFTs) are widely used for risk stratification, their static values and short‐term trends remain poorly defined in predicting persistent common bile duct stones.
Renato Pitesa, Wai Yan (Rachel) Yuen, Nadia Meyer, Garth Poole, Primal Parry Singh   +4 more
wiley   +1 more source

Intrahepatic bile duct strictures in a liver allograft recipient mimicking recurrent primary sclerosing cholangitis - Follow-up of a case report [PDF]

, 1991
Demetris, AJ, Gordon, R, Hartman, GG, Lerut, J, Starzl, TE   +4 more
core   +1 more source

Surgical complications in human orthotopic liver transplantation. [PDF]

, 1987
Between March 1, 1980 and December 31, 1984, 393 orthotopic liver transplantations (OLT) were performed in 313 consecutive recipients. Technical complications were responsible for a substantial morbidity (41/393 allograft loss--10.4%) and mortality (26 ...
Gordon, RD, Iwatsuki, S, Lerut, J, Starzl, TE   +3 more
core  

Skin Cancers in Australian Liver Transplant Recipients: Risk Factors and Histology

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Skin cancer is one of the most common comorbidities for liver transplant recipients (LTRs). Carcinogenesis is a multifaceted process: immunosuppression and personal risk factors such as smoking status, UV exposure, past history of skin cancer and family history of skin cancer can all play a significant role in determining the extent
Rohan Rajaram, Gehan Premaratne, Charlotte Tiplady, Evania Lok, Angela Li, Avik Majumdar, Robert Jones, Sally Kiu‐Huen Ng   +7 more
wiley   +1 more source

Assessing Major Adverse Liver Outcomes With Baclofen Compared to Acamprosate in Compensated Alcohol‐Associated Cirrhosis

Alimentary Pharmacology &Therapeutics, EarlyView.
We conducted a nationwide, multicenter cohort study using a target trial emulation framework to compare baclofen and acamprosate in patients with compensated alcohol‐associated cirrhosis. After matching, baclofen initiation was associated with a higher 1‐year risk of major adverse liver outcomes, driven primarily by hepatic encephalopathy, particularly
Yee Hui Yeo, Sepideh Mehravar, Ellen Choi, Ju Dong Yang, Hyun‐Seok Kim, Yun Wang, Aarshi Vipani, Hirsh D. Trivedi, Walid Ayoub, Parnian Naji, Alexander Kuo, Chun‐Ying Wu, Lorenzo Leggio, Juan Pablo Arab   +13 more
wiley   +1 more source

Seladelpar Improved Itch, Itch‐Related Sleep Disturbance and Measures of Fatigue in Patients With Primary Biliary Cholangitis and Pruritus in the Phase 3 RESPONSE Trial

Alimentary Pharmacology &Therapeutics, EarlyView.
Seladelpar improved itch, itch‐related sleep disturbance and measures of fatigue in patients with primary biliary cholangitis and pruritus in the Phase 3 RESPONSE trial. ABSTRACT Background Pruritus and fatigue impose a significant burden on patient quality of life in primary biliary cholangitis (PBC).
Cynthia Levy, David E. J. Jones, Marlyn J. Mayo, Christopher L. Bowlus, Kris V. Kowdley, Gideon M. Hirschfield, Jie Liu, Caroline Burk, Susheela Carroll, Daria B. Crittenden, Andreas E. Kremer   +10 more
wiley   +1 more source

Sarcopenia Is Associated With Mortality and Progression of Cirrhosis in Decompensated but Not Compensated Disease—A Multicentre Study

Alimentary Pharmacology &Therapeutics, EarlyView.
In a retrospective cohort of 1,624 adults with cirrhosis, sarcopenia was independently associated with unplanned hospitalization, death, and cirrhosis progression (or death) in patients with decompensated disease. In compensated cirrhosis, sarcopenia was associated only with a higher risk of unplanned hospitalization.
Puneeta Tandon, Sarah Wang, Moon Young Kim, Bart Van Hoek, Daphne Bot, Jeroen L. A. van Vugt, Berend Beumer, Jan Ijzermans, Sunil Taneja, Ajay Duseja, Surender Singh, Maryam Ebadi, Aldo J. Montano‐Loza   +12 more
wiley   +1 more source

Case Report: Rare spontaneous hepatic rupture hemorrhage complicated by autoimmune liver disease

Frontiers in Medicine
Autoimmune liver disease is predominantly characterized by autoimmune hepatitis and primary biliary cholangitis. In clinical practice, patients with autoimmune liver disease may progress to cirrhosis and subsequently develop multiple complications of ...
Limin Ma, Changming Tao, Jichun Yang, Yingying Zhang, Yanan Qin   +4 more
doaj   +1 more source