Results 131 to 140 of about 4,431,933 (293)

Anti-gp210 and anti-sp100 antibody status and ursodeoxycholic acid response in primary biliary cholangitis [PDF]

, 2018
Aims: Primary biliary cholangitis is a chronic biliary liver disease, for which the prognosis is poorer in patients who do not respond satisfactorily to the mainstay of treatment, ursodeoxycholic acid.
Chapman, Roger W., Roberts, CA, Lynch, KD, Sturrock, BRH, Ferry, B, Rogers, Jennifer, Sadler, R, Sturrock, Beattie R.H., Lynch, Kate D., Chapman, RW, Rogers, J   +10 more
core   +1 more source

Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions

Portal Hypertension &Cirrhosis, EarlyView.
This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley   +1 more source

Novel biomarkers for primary biliary cholangitis to improve diagnosis and understand underlying regulatory mechanisms

, 2019
Background and aims: Primary biliary cholangitis is an autoimmune biliary disease characterized by injury of bile ducts, eventually leading to cirrhosis and death.
Muratori L., Moro M., Geginat J., Terracciano L. M., Abrignani S., Grifantini R., Torri A., Crosti M., Sinisi A., Bernuzzi F., Carpi D., Cordiglieri C., Gerussi A., Bombaci M., Pesce E., Invernizzi P., Lanzafame M.   +16 more
core   +1 more source

Analysis of C4 Concentrations to Predict Impact of Patient‐Reported Diarrhea Associated With the Ileal Bile Acid Transporter Inhibitor Linerixibat

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.
ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño, Rashmi Mehta, Andrea Ribeiro de Souza, Jon Collins, Brandon Swift   +4 more
wiley   +1 more source

Protein Corona Engineering of Lipid Nanoparticles Enables Efficient Functional Gene Silencing in the Liver

Small, EarlyView.
By shaping the protein corona, lipid composition directs LNP tropism and enables the preferential delivery of a TIMP1‐targeting siRNA to liver macrophages. In a murine model of primary biliary cholangitis, this strategy promoted macrophage reprogramming and attenuated liver fibrosis.
Naths G. Sukubo, Serena Renzi, Martina B. Violatto, Leila Altigieri, Anna L. Capriotti, Andrea Cerrato, Aldo Laganà, Luca Digiacomo, Erica Quagliarini, Antonio Minopoli, Massimiliano Papi, Daniela Pozzi, Carlo A. Scirè, Pietro Invernizzi, Paolo Bigini, Giulio Caracciolo   +15 more
wiley   +1 more source

Primary Biliary Cholangitis: Epidemiology, Diagnosis, and Presentation

Using ursodeoxycholic acid as a standard treatment and for its ability to test for antimitochondrial antibody to accelerate diagnosis, survival of primary biliary cholangitis patients has approached that of the general population, leading to a change in ...
Gordon, Stuart C, Gonzalez, Humberto C, Faisal, Muhammad S   +2 more
core   +1 more source

Cholangiocyte organoids for disease, cancer, and regenerative medicine

European Journal of Cell Biology
The biliary tract is a ductal network comprising the intrahepatic (IHBDs) and extrahepatic bile duct (EHBDs). Biliary duct disorders include cholangitis, neoplasms, and injury. However, the underlying mechanisms are not fully understood.
Munemasa Nagao, Akihisa Fukuda, Hirotaka Kashima, Sho Matsuyama, Kei Iimori, Shinnosuke Nakayama, Kenta Mizukoshi, Munenori Kawai, Go Yamakawa, Mayuki Omatsu, Mio Namikawa, Tomonori Masuda, Yukiko Hiramatsu, Yu Muta, Takahisa Maruno, Yuki Nakanishi, Tatsuaki Tsuruyama, Hiroshi Seno   +17 more
doaj   +1 more source

Surgical Appropriateness of Imaging in Acute Cholecystitis: A Danish Audit

Surgical Practice, EarlyView.
ABSTRACT Background Acute cholecystitis is a common surgical condition, most frequently caused by gallstones. Ultrasound is recommended as the first‐line imaging modality, while CT and MRCP are reserved for inconclusive cases or suspected complications. Increasing use of CT in Denmark raises concerns regarding unnecessary radiation exposure. This study
Daniel Bornemann, Tobias Nord Neustrup, Anders Dalgaard Andersen, Sandra Soerensen, Theis Christmas Moeller, Peter Derek Christian Leutscher, Kathrine Holte   +6 more
wiley   +1 more source

Cost‐Effectiveness of Laparoscopic Common Bile Duct Exploration Versus Endoscopic Retrograde Cholangiopancreatography in Emergency Stone Management

ANZ Journal of Surgery, EarlyView.
Among 337 patients undergoing emergency management of common bile duct stones, laparoscopic common bile duct exploration was associated with lower healthcare costs, fewer procedures and shorter hospital stays than ERCP‐based management, supporting single‐stage surgical management as a safe and cost‐effective treatment strategy.
Tess Howard, Lily Owens, Harendra Maneesha De Silva, Darren Lowen, David Bird, Russell Hodgson   +5 more
wiley   +1 more source

The use of transferrin isoforms to differentiate cholestatic liver diseases

Studia Medyczne
Introduction There are two main chronic autoimmune cholestatic liver diseases, primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), which may lead to liver fibrosis or cirrhosis and consequent disturbances in protein and ...
Lech Chrostek, Alicja Bauer, Ewa Gruszewska, Bogdan Cylwik   +3 more
doaj   +1 more source