Results 161 to 170 of about 4,431,933 (293)

Allelic variation in the TNF-beta gene does not explain the low TNF-beta response in patients with primary biliary cirrhosis [PDF]

, 1991
Eisenburg, Josef, E. H. WEISS, E. D. ALBBRT, G. R. PAPE, Pape, Gerd R., G. HONOLD, G. RIETHMÜLLER, S. SCHOLZ, G. MESSER, Riethmüller, Gert, Albert, E. D., U. SPENGLER, J. EISENBURG, Spengler, Ulrich, Honold, G., M. C. JUNG, Messer, Gerald, Jung, Maria C., Weiss, Elisabeth H., Scholz, S.   +19 more
core   +1 more source

Rare Variants in PFIC‐Related Genes Among Adults With Intrahepatic Cholestasis

Hepatology Research, EarlyView.
ABSTRACT Aim Biallelic pathogenic variants in progressive familial intrahepatic cholestasis (PFIC)‐related genes cause severe pediatric cholestasis. However, the clinical significance of heterozygous variants in adult intrahepatic cholestasis remains unclear.
Shunji Hirose, Kota Tsuruya, Yusuke Mishima, Yoshitaka Arase, Koichi Shiraishi, Vu Thi Hao, Satsuki Ieda, Masayuki Tanaka, Sanae Isaki, Tatehiro Kagawa   +9 more
wiley   +1 more source

Pemafibrate Improves Cholestatic Markers Regardless of the Presence of Primary Biliary Cholangitis

Hepatology Research, EarlyView.
Pemafibrate improves liver function markers related to bile flow in primary biliary cholangitis (PBC), but whether this effect is disease‐specific remains unclear. In this study, pemafibrate reduced these markers in patients with and without PBC, suggesting broader effects on bile flow beyond PBC.
Ryohei Tanigawa, Yoshiyuki Ueno, Hirokazu Takahashi, Ayumi Saito, Hideki Suganami, Atsushi Tanaka   +5 more
wiley   +1 more source

Stability and Variability of Symptom Burden in Primary Biliary Cholangitis: Insights From a Decade of Follow‐Up

Hepatology Research, EarlyView.
Impairment of health‐related quality of life in patients with PBC, in particular observed in younger female, represents distinct dimensions of disease impact, independently of long‐term outcomes. Overall and interindividual changes in PBC‐40 scores greatly varied over 10 years, suggesting that symptom burdens are driven by heterogeneous underlying ...
Akihito Takeuchi, Atsumasa Komori, Kazuhito Kawata, Osamu Yoshida, Kazunari Tanaka, Kazumichi Abe, Yukihisa Fujinaga, Tadashi Namisaki, Naruhiro Kimura, Tomohiro Katsumi, Ryo Miura, Naoko Tachizawa, Yoshinari Asaoka, Yoshiyuki Ueno, Shuji Terai, Hiromasa Ohira, Hitoshi Yoshiji, Kentaro Kikuchi, Takeshi Matsui, Tadashi Ikegami, Akira Honda, Masanori Abe, Atsushi Tanaka   +22 more
wiley   +1 more source

Hepatic Carcinoma With Epithelial–Myoepithelial Differentiation and Metachronous Intrahepatic Recurrence Following Curative Resection: A Rare Case Report

Hepatology Research, EarlyView.
ABSTRACT Background and Aim Epithelial‐myoepithelial carcinoma (EMC), a malignant tumor with biphasic epithelial and myoepithelial differentiation, is typically a salivary gland neoplasm. Contrastingly, myoepithelial carcinoma (MEC) predominantly comprises myoepithelial cells.
Ryo Nagao, Tomoyuki Abe, Masateru Yamamoto, Yuki Imaoka, Naruhiko Honmyo, Seiichi Shimizu, Shintaro Kuroda, Hiroyuki Tahara, Masahiro Ohira, Kentaro Ide, Tsuyoshi Kobayashi, Tetsuya Nakagiri, Koji Arihiro, Hideki Ohdan   +13 more
wiley   +1 more source

Histological AI‐Assisted Analysis Outperforms Pathologist Assessment in Predicting Disease Outcomes in PSC Patients

Hepatology Research, EarlyView.
Analyzing liver histology with AI assistance demonstrates superior prognostic performance compared to manual scoring in PSC. AI‐measured portal inflammation, fibrosis, biliary epithelium, and blood vessels predicted key clinical endpoints, such as liver transplantation due to end‐stage liver disease, highlighting the importance of liver histology as a ...
Anna M. Salonen, Iiris Nyholm, Linn Tähti, Matilda Sinkko, Darshan Kumar, Martti Färkkilä, Johanna Arola, Mikko P. Pakarinen, Sonja Boyd, Nelli Sjöblom   +9 more
wiley   +1 more source

Indoleamine 2,3‐Dioxygenase 1 as an Adjunctive Histopathological Marker of Cholangitis Activity in Primary Biliary Cholangitis

Hepatology Research, EarlyView.
IDO‐1 immunostaining identifies primary biliary cholangitis even in morphologically subtle bile duct lesions. IDO‐1 expression reflects cholangitis activity and is suppressed by ursodeoxycholic acid treatment, indicating its value as a dynamic diagnostic adjunct rather than a static marker of chronic damage.
Kaori Yoshimura, Shinji Shimoda, Ryoka Masuda, Tram Nguyen Thi, Rui Yang, Quynh Nguyen Thi, Dong Le Thanh, Yuko Tamano, Yasunori Sato, Taro Yamashita, Kenichi Harada   +10 more
wiley   +1 more source

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis.

New England Journal of Medicine, 2016
F. Nevens, P. Andreone, G. Mazzella, S. Strasser, C. Bowlus, P. Invernizzi, J. Drenth, P. Pockros, J. Reguła, U. Beuers, M. Trauner, Dave E. Jones, A. Floreani, S. Hohenester, V. Luketic, M. Shiffman, K. V. van Erpecum, V. Vargas, C. Vincent, G. Hirschfield, Hemant A. Shah, B. Hansen, K. Lindor, H. Marschall, K. Kowdley, R. Hooshmand-Rad, T. Marmon, S. Sheeron, R. Pencek, L. Macconell, M. Pruzanski, D. Shapiro   +31 more
semanticscholar   +1 more source

Clinical Outcomes of Gradual Corticosteroid Tapering for Immune Checkpoint Inhibitor‐Induced Liver Injury

Hepatology Research, EarlyView.
Patients with severe ICI‐induced liver injury are commonly treated with corticosteroids, but the optimal tapering strategy remains uncertain. In this study, a gradual corticosteroid tapering strategy based partly on Japanese clinical practice for autoimmune hepatitis was associated with a low rate of relapse and enabled many patients to safely resume ...
Naoto Soma, Yoshihito Uchida, Kayoko Sugawara, Masamitsu Nakao, Nobuaki Nakayama, Yukinori Imai, Suguru Mizuno, Satoshi Mochida   +7 more
wiley   +1 more source

EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis.

Journal of Hepatology, 2017
G. Hirschfield, U. Beuers, C. Corpechot, P. Invernizzi, D. Jones, M. Marzioni, C. Schramm   +6 more
semanticscholar   +1 more source