Results 41 to 50 of about 48,450 (199)

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Association Between Liver Function Grade and Post‐Hepatectomy Liver Failure in Patients With Hepatocellular Carcinoma: A Latent Class Analysis

Annals of Gastroenterological Surgery, EarlyView.
We retrospectively analyzed clinical data from patients who underwent hepatectomy for hepatocellular carcinoma (HCC) using LCA‐based grading system. These findings provide a new risk stratification framework for the design of precision surgery to treat patients with HCC.
Ling Liu, Jintao Zheng, Ye Wang, Chenao Yang, Jiachen Zhang, Changku Jia   +5 more
wiley   +1 more source

Serum Bile Acids Are Useful Indicators of Intrahepatic Recurrence After Initial Curative Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Bile acids accumulation in hepatocytes causes liver damage and contributes to the development of hepatocellular carcinoma. However, the association between serum bile acid levels and postoperative intrahepatic recurrence in hepatocellular carcinoma remains unclear.
Tomoaki Bekki, Masahiro Ohira, Yuki Imaoka, Seiichi Simizu, Tomoyuki Abe, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Hideki Ohdan   +9 more
wiley   +1 more source

Predicting outcome in primary biliary cirrhosis

Annals of Hepatology, 2014
Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune liver disease that may ultimately result in liver failure and premature death. Predicting outcome is of key importance in clinical management and an essential requirement for patients ...
Willem J. Lammers, Kris V. Kowdley, Henk R. van Buuren   +2 more
doaj   +1 more source

Surgical Outcomes and Recurrence Management in Borderline Resectable Hepatocellular Carcinoma: Implications for Multidisciplinary Strategies

Annals of Gastroenterological Surgery, EarlyView.
Multivariate analysis identified that up‐to‐7 out (p < 0.001), lymph node metastasis (p < 0.001), and non‐anatomical resection (p = 0.02) were independent predictors of cancer recurrence, while older age (p = 0.01), Child‐Pugh B (p < 0.001), up‐to‐7 out (p = 0.01), macrovascular invasion (p = 0.01), and lymph node metastasis (p < 0.001) were ...
Koichiro Haruki, Kenei Furukawa, Munetoshi Akaoka, Yuto Yamahata, Shinji Onda, Yoshihiro Shirai, Masashi Tsunematsu, Tomohiko Taniai, Michinori Matsumoto, Toru Ikegami   +9 more
wiley   +1 more source

Primary biliary cirrhosis associated pustular vasculitis

Annals of Hepatology, 2006
The association between primary biliary cirrhosis (PBC) and cutaneous vasculitides is well recognized. Pustular skin lesions though, have been described in association with hepatobiliary diseases other than PBC.
A. Koulaouzidis, S. Campbell, A. Bharati, N. Leonard, R. Azurdia   +4 more
doaj   +1 more source

Robotic Versus Laparoscopic Anatomic Liver Resection: Comparison of Perioperative Outcomes—A Systematic Review and Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
Minimally invasive anatomic liver resection (AR) including major hepatectomy and liver parenchyma‐sparing AR is technically complex and demanding. This systematic review with meta‐analysis including 15 studies comparing 2042 robotic AR and 2129 laparoscopic AR patients demonstrated largely comparable perioperative outcomes and partly better outcomes ...
Yutaro Kato, Atsushi Sugioka, Hiroyuki Kato, Akihiko Horiguchi   +3 more
wiley   +1 more source

An Asymptomatic Male with Coexisting Celiac Disease and Primary Biliary Cirrhosis

Canadian Journal of Gastroenterology, 1991
Both primary biliary cirrhosis and celiac disease may be asymptomatic in many patients for extended periods of time. Rarely the disorders have been reported to occur together, in which case symptomatic malabsorption and diarrhea are virtually always ...
Franzjosef Schweiger, Jasim Radhi
doaj   +1 more source

Colangiopatia auto-imune.

Acta Médica Portuguesa, 2001
We report two patients with mixed characteristics of primary biliary cirrhosis and autoimmune hepatitis. They are two female patients in their fifties (54 and 58 years-old) one of them with autoimmune phenomenon, rheumatoid arthritis and Sjögren syndrome.
R Marinho, H Graça, F Ramalho, A Costa, A Batista, M C De Moura   +5 more
doaj   +1 more source

Autosomal Dominant Erythrocytosis Caused by Non‐Renal Erythropoietin (EPO) Due to EPO c.‐136 G>A Germline Mutation

American Journal of Hematology, EarlyView.
A novel erythropoietin (EPO) promoter mutation (c.‐136 G>A) causes autosomal dominant erythrocytosis via non‐renal expression of EPO. ABSTRACT We previously reported a five‐generation kindred with autosomal dominant erythrocytosis associated with a novel germline promoter variant in the erythropoietin (EPO) gene (EPO c.‐136 G>A).
Lucie Lanikova, Dusan Hrckulak, Veronika Zimolova, Felipe R. Lorenzo, Jihyun Song, Katerina Vecerkova, Olga Babosova, Linda Berkova, Vladimir Korinek, Steve Elliott, Josef T. Prchal   +10 more
wiley   +1 more source