Results 81 to 90 of about 11,134,118 (343)

The asthma diagnosis jigsaw puzzle: an adaptable teaching concept to facilitate the diagnosis of asthma in adults and children presenting to primary care

npj Primary Care Respiratory Medicine
The asthma diagnosis jigsaw puzzle is a clinical practice and teaching concept conceived in clinical practice and refined through an expert multidisciplinary consensus process by academics and clinicians with an interest in primary respiratory care.
D. Ryan, J. W. H. Kocks, S. Williams, J. Correia de Sousa, M. Barne, M. J. Bates, I. Bouloukaki, L. Daines, E. Gaillard, V. Mak, A. Ostrem, A. Barnard   +11 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Fidelity evaluation of the compared procedures for conducting the PVS-PREDIAPS implementation strategy to optimize diabetes prevention in primary care

BMC Family Practice, 2021
Background Assessing the fidelity of an implementation strategy is important to understand why and how the strategy influences the uptake of evidence-based interventions.
Alvaro Sánchez, Heather L. Rogers, Susana Pablo, Esther García, Inmaculada Rodríguez, Mª. Antonia Flores, Olga Galarza, Ana B. Gaztañaga, Pedro A. Martínez, Eider Alberdi, Elena Resines, Ana I. Llarena, Gonzalo Grandes, on behalf of the PREDIAPS Group   +13 more
doaj   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Contributing barriers to loss to follow up from antenatal care services in villages around Addis Ababa: a qualitative study

BMC Women's Health, 2021
Background Problems during pregnancy, childbirth and postpartum are the major contributors to maternal and perinatal morbidity and mortality. Focused antenatal care is an intervention set to provide basic services for pregnant women, to reduce morbidity ...
Zergu Tafesse Tsegaye, Hailemariam Segni Abawollo, Binyam Fekadu Desta, Tsega Teferi Mamo, Atrie Fekadu Heyi, Mestawot Getachew Mesele, Addisu Dabesa Lose   +6 more
doaj   +1 more source

Primary Care and Primary Care Training: Mirror Images [PDF]

Journal of General Internal Medicine, 2010
Primary care appears to be in a perpetual state of crisis. The failures are well known. Primary care physicians work in stressful, under-resourced work environments with overcrowded schedules geared towards acute care. Chronic disease patients receive inadequate treatment and physicians lack the time, expertise and money to systematically measure and ...
Eric J. Warm, Emily L. Leasure
openaire   +3 more sources

Nurses as substitutes for doctors in primary care

Cochrane Database of Systematic Reviews, 2018
Background Current and expected problems such as ageing, increased prevalence of chronic conditions and multi‐morbidity, increased emphasis on healthy lifestyle and prevention, and substitution for care from hospitals by care provided in the community ...
M. Laurant, Mieke van der Biezen, Nancy Wijers, Kanokwaroon Watananirun, E. Kontopantelis, A. V. van Vught   +5 more
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Standards of Medical Care in Diabetes—2019 Abridged for Primary Care Providers

Clinical Diabetes, 2018
The American Diabetes Association’s (ADA’s) Standards of Medical Care in Diabetes is updated and published annually in a supplement to the January issue of Diabetes Care.

semanticscholar   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source