Results 81 to 90 of about 7,840,227 (263)

Diabetes care provision in UK primary care practices [PDF]

, 2012
Background: Although most people with Type 2 diabetes receive their diabetes care in primary care, only a limited amount is known about the quality of diabetes care in this setting.
Martin P Eccles, Hawthorne, G., Elovainio Marko, Stamp, Elaine, Steen Nick, Grimshaw, J. M., Francis, Jill J., Margaret Hunter, Elaine Stamp, Stamp, E., Eccles, MP, Jill J Francis, Stamp Elaine, Eccles, Martin P, Susan Hrisos, Hunter, M., Eccles, M. P., Hawthorne, Gillian, Jeremy M Grimshaw, Hrisos, S, Francis, J., Martin P. Eccles, Eccles, Martin P., Hrisos Susan, Eccles Martin P., Presseau Justin, Justin Presseau, Francis Jill J., Grimshaw Jeremy M., Hunter Margaret, Stamp, E, Hawthorne Gillian, Marie Johnston, Francis, JJ, Grimshaw, JM, Steen, N., Presseau, Justin, Gillian Hawthorne, Steen, Nick, Hawthorne, G, Francis, Jill J, Johnston Marie, Elovainio, Marko, Hrisos, S., Jill J. Francis, Marko Elovainio, Johnston, M, Steen, N, Presseau, J, Johnston, M., Elovainio, M., Elovainio, M, Grimshaw, Jeremy M, Grimshaw, Jeremy M., Hunter, Margaret, Presseau, J., Johnston, Marie, Nick Steen, Hunter, M, Hrisos, Susan, Jeremy M. Grimshaw   +60 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Determinants of frailty in primary care patients with COPD: the Greek UNLOCK study

BMC Pulmonary Medicine, 2019
Background Frailty is a state of increased vulnerability that has a significant risk of unfavorable outcomes such as increased dependency and/or death, but little is known about frailty in people with chronic obstructive pulmonary disease (COPD).
Despo Ierodiakonou, Maria Kampouraki, Ioannis Poulonirakis, Polyvios Papadokostakis, Eleftheria Lintovoi, Dimitris Karanassos, Kyriakos Maltezis, Maria Chorti, Evangelos Petrovitsos, Sofia Dimopoulou, Sam Hamind, Ioannis Gialamas, Polyxeni Athanasiou, Vasiliki Bempi, Irene Lambraki, Ioanna Tsiligianni   +15 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Creating space to talk about patients\u2019 personal goals : experiences from primary care stakeholders

, 2023
: Background To address the many challenges health systems and communities face, primary care is constantly searching for new strategies to improve quality of care.
Vert\ue9, Emily, Gauwe, Vanessa, De Vriendt, Patricia, Decat, Peter, Buffel, Veerle, Claeys, Tony, Vandenhoudt, Hilde, Primary Care Acad, Schoenmakers, Birgitte, Pless, Sam, Van Landschoot, Leen, Huybrechts, Ine, Lahousse, Lies, Foulon, Veerle, Lopez Hartmann, Maja, Van den Broeck, Kris, Rutten, Erica, Timmermans, Lotte, Roose, Rudi, Verhaeghe, Nick, Pype, Peter, Martin, Sandra, Van de Velde, Dominique, De Loof, Hans, Remmen, Roy, Devroey, Dirk, De Vliegher, Kristel, Sirimsi, Muhammed Mustafa, Boeykens, Dagje, Van Bogaert, Peter, Anthierens, Sibyl, De Sutter, An, Haverals, Reini, Boeckxstaens, Pauline, Raeymaeckers, Peter, Aertgeerts, Bert, Van Hecke, An, Declerq, Anja, Reynaert, Didier   +38 more
core  

Encouraging primary care research : evaluation of a one-year, doctoral clinical epidemiology research course [PDF]

, 2016
Objective: Research and PhDs are relatively rare in family medicine and primary care. To promote research, regular one-year research courses for primary care professionals with a focus on clinical epidemiology were started.
Helena Liira, Hans Thulesius, Kaisu Pitkälä, Pitkälä, Kaisu,, Liira, Helena, Tuomas Koskela, Thulesius, Hans, Liira, Helena,, Pitkala, Kaisu, Thulesius, Hans,, Koskela, Tuomas, Koskela, Tuomas,   +11 more
core   +1 more source