Results 131 to 140 of about 25,833,379 (292)
Brassinin, a phytoalexin derived primarily from Chinese cabbage, exhibits potent anticancer activity against glioblastoma (GBM). Mechanistically, brassinin treatment elevates intracellular ROS levels in GBM cells, triggering two parallel outcomes: (i) direct induction of apoptosis, and (ii) suppression of cytoprotective autophagy through downregulation
Sunil Rauniyar +7 more
wiley +1 more source
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng +6 more
wiley +1 more source
Study of Primary Central Nervous System Lymphoma
背景 原發性中樞神經系統淋巴瘤(primary central nervous system lymphoma; PCNSL)是一個罕見的淋巴瘤,定義上須於診斷時只有中樞神經或腦膜受侵犯才可診斷為PCNSL。其病理組織型態,絕大多數被歸於瀰漫性大B細胞淋巴瘤(diffuse large B-cell lymphoma; DLBCL),這與一般源自週邊淋巴結(nodal lymphoma; NL)的瀰漫性大B細胞淋巴瘤在病理組織型態上並無法區分,然而這兩者的臨床表現及治療預後均有明顯的不同 ...
林璟宏, Lin, Ching-Hung
core
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko +3 more
wiley +1 more source
Schematic illustration showing that Hinokitiol promotes neural repair after spinal cord injury by activating the Keap1/Nrf2/HO‐1 signaling pathway and reprogramming microglial inflammatory‐redox responses. ABSTRACT Secondary neuroinflammation and oxidative stress, driven partly by maladaptive microglial activation, limit recovery after spinal cord ...
Wenhao Zhang +10 more
wiley +1 more source
Clinical periodontal diagnosis
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi +5 more
wiley +1 more source
Primary central nervous system lymphoma (PCNSL)
Elizabete Maria Pereira de Andrade Caires +5 more
doaj +1 more source
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley +1 more source
The role of the host—Neutrophil biology
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Scope: This guideline is aimed at providing healthcare professionals with clear guidance on the diagnosis and management of primary central nervous system lymphoma (PCNSL), defined as diffuse large B‐cell lymphoma (DLBCL) solely confined to the central ...
Linton, Kim +15 more
core +1 more source

