Results 131 to 140 of about 5,628,138 (356)

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Strategic Design of Soft Actuators in Translational Medical Robotics for Human‐Centered Healthcare

Advanced Robotics Research, EarlyView.
Soft robotics enables biocompatible, compliant medical devices, but clinical translation requires design‐driven engineering beyond materials. This perspective reviews implantable, surgical, and wearable systems by actuation mechanism, highlighting how optimized architectures and integration improve mechanical interfacing, adaptability, and durability ...
Ho Jun Jin, Jimin Kim, Inho Kim, Bong Hoon Kim   +3 more
wiley   +1 more source

Acute inhibition of centriolar satellite function and positioning reveals their functions at the primary cilium

bioRxiv, 2020
Centriolar satellites are dynamic, membrane-less granules composed of over 200 proteins. They store, modify, and traffic centrosome and primary cilium proteins, and help to regulate both the biogenesis and some functions of centrosomes and cilium.
Ozge Z. Aydin, Sevket Onur Taflan, Can Gurkaslar, E. N. Firat-Karalar   +3 more
semanticscholar   +1 more source

Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2 [PDF]

, 2012
Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is sensed by the embryo.
A. Kawasumi, B. Dworniczak, B. E. Ehrlich, Collignon, Ermakov, G. Sasaki, Gonzalez-Perrett, H. Hamada, H. Sasaki, H. Shiratori, Hirokawa, I. Y. Kuo, J. A. Belo, J. Nakai, K. Shinohara, Koulen, Marques, Marszalek, McGrath, Nauli, Nonaka, P. Pennekamp, Pazour, Pennekamp, Rankin, REYNOLDS, S. Nonaka, S. Yoshiba, Schweickert, Shinohara, Tabin, Tanaka, Tanaka, Y. Asai   +33 more
core   +1 more source

The Centrosome and the Primary Cilium: The Yin and Yang of a Hybrid Organelle

Cells, 2019
Centrosomes and primary cilia are usually considered as distinct organelles, although both are assembled with the same evolutionary conserved, microtubule-based templates, the centrioles.
V. Joukov, A. De Nicolo
semanticscholar   +1 more source

Primary cilium polarity: morphogenetic consequences.

, 2018
In zebrafish inner ear, hair cell orientation in anterior and posterior maculae of the embryonic otic vesicle is different (about 30-40 degrees): this is rather unusual in planar polarity mechanism of action, instead suggests that kinocilia may be rotationally polarized.
openaire   +2 more sources

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish

BMC Biology, 2010
Background In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway.
van Eeden Freek, Richardson Joanna, Kim Hyejeong, Ingham Philip W   +3 more
doaj   +1 more source

Non-newtonian 3D ciliary fluid flow in a semi-infinite domain [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011), Danaila, S, Isvoranu, D   +2 more
core  

Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures [PDF]

, 2019
Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of ...
Antonellis, Patrick J., Bansal, Ruchi, Baucum, Anthony J., Berbari, Nicolas F., Cummins, Theodore R., Engle, Staci E., Reiter, Jeremy F., Whitehouse, Logan S.   +7 more
core   +1 more source