Results 241 to 250 of about 4,814,966 (373)

A Systematic Review of the Variability of Ventilation Defect Percent Generated From Hyperpolarized Noble Gas Pulmonary Magnetic Resonance Imaging

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Hyperpolarized (HP) gas pulmonary MR ventilation images are typically quantified using ventilation defect percent (VDP); however, the test‐retest variability of VDP has not been systematically established in multi‐center trials. Herein, we perform a systematic review of the test‐retest literature on the variability of VDP, and similar metrics,
Vanessa M. Diamond, Laura C. Bell, Jeffrey N. Bone, Bastiaan Driehuys, Martha Menchaca, Giles Santyr, Sarah Svenningsen, Robert P. Thomen, Helen Marshall, Laurie J. Smith, Guilhem J. Collier, Jim M. Wild, Jason C. Woods, Sean B. Fain, Rachel L. Eddy, Jonathan H. Rayment   +15 more
wiley   +1 more source

Nasal Mucosa Regeneration After Reboot Surgery: Electron Microscopy and Histology Insights in CRSwNP

The Laryngoscope, EarlyView.
CRSwNP often requires multiple treatments, with monoclonal antibodies (mAbs) and endoscopic sinus surgeries used to manage resistant cases. This study focused on five patients undergoing reboot surgery, analyzing mucosal regeneration through biopsies and clinical outcomes over 24 months. It revealed complete non‐scarred regeneration of the nasal mucosa,
Francesca Pirola, Elena Vezzoli, Andrea Falqui, Francesco Giombi, Enrico Heffler, Giuseppe Mercante, Giuseppe Spriano, Fabio Grizzi, Luca Malvezzi   +8 more
wiley   +1 more source

Hedgehog-Stimulated Chemotaxis Is Mediated by Smoothened Located Outside the Primary Cilium [PDF]

, 2012
Maarten F. Bijlsma, Helene Damhofer, Henk Roelink   +2 more
openalex   +1 more source

The miR‐669a‐5p/G3BP/HDAC6/AKAP12 Axis Regulates Primary Cilia Length

Advanced Science
Primary cilia are conserved organelles in most mammalian cells, acting as “antennae” to sense external signals. Maintaining a physiological cilium length is required for cilium function.
Weina Wang, Xuyao Dai, Yue Li, Mo Li, Zongqi Chi, Xiaoyu Hu, Zhenshan Wang   +6 more
doaj   +1 more source

Deciphering vesicle-assisted transport mechanisms in cytoplasm to cilium trafficking

Frontiers in Cellular Neuroscience
The cilium, a pivotal organelle crucial for cell signaling and proper cell function, relies on meticulous macromolecular transport from the cytoplasm for its formation and maintenance.
Mark Tingey, Andrew Ruba, Zechang Jiang, Weidong Yang   +3 more
doaj   +1 more source

A direct interaction between CENTLEIN and RABIN8 is required for primary cilium formation. [PDF]

Acta Biochim Biophys Sin (Shanghai), 2023
Li L, Li J, Yuan L.
europepmc   +1 more source

Monitoring Euplotes species dynamics in mixed experiments using genetic markers for quantitative polymerase chain reaction

Limnology and Oceanography: Methods, EarlyView.
Abstract Ciliates are widespread and play a major role in ecosystems as they form an important link between primary producers and higher trophic levels. They have been used as a classic model to study predator–prey interactions of co‐evolutionary processes.
Verena Bamberger, Ralph Tollrian, Linda C. Weiss   +2 more
wiley   +1 more source

Primary cilium-mediated MSC mechanotransduction is dependent on Gpr161 regulation of hedgehog signalling.

Bone, 2021
G. Johnson, S. Fair, D. Hoey
semanticscholar   +1 more source

In Situ Gels for Nasal Delivery: Formulation, Characterization and Applications

Macromolecular Materials and Engineering, EarlyView.
Drug delivery through the nasal route offers many advantages, but is hampered by a number of challenges, such as the short drug retention time caused by mucociliary clearance. In situ forming gels, which undergo a sol‐to‐gel transition with specific triggers at the site of action, present real opportunities in this field.
Li Qian, Michael T. Cook, Cécile A. Dreiss   +2 more
wiley   +1 more source

The inhibition of MDM2 slows cell proliferation and activates apoptosis in ADPKD cell lines

Biology of the Cell, Volume 115, Issue 1, January 2023., 2023
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a pathology characterised by the formation of kidney cists that impair renal function. The wall of renal cysts is covered with cystic cells that show increased activation of mTOR. Abnormal mTOR activation inhibits autophagy, promotes the degradation of TP53 by the proteasome in a mechanism ...
Simone Patergnani, Antonino Giattino, Nicoletta Bianchi, Carlotta Giorgi, Paolo Pinton, Gianluca Aguiari   +5 more
wiley   +1 more source