Results 61 to 70 of about 4,977,244 (269)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Partner notification and partner treatment for chlamydia: attitude and practice of general practitioners in the Netherlands; a landscape analysis

BMC Family Practice, 2017
Background Chlamydia prevalence remains high despite scaling-up control efforts. Transmission is not effectively interrupted without partner notification (PN) and (timely) partner treatment (PT).
Ingrid V. F. van den Broek, Gé A. Donker, Karin Hek, Jan E. A. M. van Bergen, Birgit H. B. van Benthem, Hannelore M. Götz   +5 more
doaj   +1 more source

Conducting public health surveillance in areas of armed conflict and restricted population access: a qualitative case study of polio surveillance in conflict-affected areas of Borno State, Nigeria

Conflict and Health, 2022
This study examined the impact of armed conflict on public health surveillance systems, the limitations of traditional surveillance in this context, and innovative strategies to overcome these limitations.
Eric Wiesen, Raymond Dankoli, Melton Musa, Jeff Higgins, Joseph Forbi, Jibrin Idris, Ndadilnasiya Waziri, Oladapo Ogunbodede, Kabiru Mohammed, Omotayo Bolu, Gatei WaNganda, Usman Adamu, Eve Pinsker   +12 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

National key performance indicators for Aboriginal and Torres Strait Islander primary health care: results from December 2013 [PDF]

, 2014
Captures data from over 200 primary health care organisations that receive funding from the Australian Government Department of Health to provide services primarily to Aboriginal and Torres Strait Islander people.

core  

Diabetes care provision in UK primary care practices [PDF]

, 2012
Background: Although most people with Type 2 diabetes receive their diabetes care in primary care, only a limited amount is known about the quality of diabetes care in this setting.
Martin P Eccles, Hawthorne, G., Elovainio Marko, Stamp, Elaine, Steen Nick, Grimshaw, J. M., Francis, Jill J., Margaret Hunter, Elaine Stamp, Stamp, E., Eccles, MP, Jill J Francis, Stamp Elaine, Eccles, Martin P, Susan Hrisos, Hunter, M., Eccles, M. P., Hawthorne, Gillian, Jeremy M Grimshaw, Hrisos, S, Francis, J., Martin P. Eccles, Eccles, Martin P., Hrisos Susan, Eccles Martin P., Presseau Justin, Justin Presseau, Francis Jill J., Grimshaw Jeremy M., Hunter Margaret, Stamp, E, Hawthorne Gillian, Marie Johnston, Francis, JJ, Grimshaw, JM, Steen, N., Presseau, Justin, Gillian Hawthorne, Steen, Nick, Hawthorne, G, Francis, Jill J, Johnston Marie, Elovainio, Marko, Hrisos, S., Jill J. Francis, Marko Elovainio, Johnston, M, Steen, N, Presseau, J, Johnston, M., Elovainio, M., Elovainio, M, Grimshaw, Jeremy M, Grimshaw, Jeremy M., Hunter, Margaret, Presseau, J., Johnston, Marie, Nick Steen, Hunter, M, Hrisos, Susan, Jeremy M. Grimshaw   +60 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]

, 2012
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
Knight, M.M., A. K. T. Wann, Wann, A.K.T., Knight, MM, Wann, AKT, M. M. Knight   +5 more
core   +1 more source

Desenvolvimento de uma medida de controle primário e secundário para idosos

Psicologia: Teoria e Pesquisa
Apresenta-se neste artigo um instrumento desenvolvido para avaliar os processos adaptativos de controle primário e controle secundário em idosos. Controle primário é definido como uma estratégia utilizada para modificar o ambiente, visando adequá-lo às ...
Hilma Tereza Tôrres Khoury, Isolda de Araújo Günther   +1 more
doaj   +1 more source

Estimating health service utilization potential using the supply-concentric demand-accumulation spatial availability index: a pulmonary rehabilitation case study

International Journal of Health Geographics, 2020
The potential for a population at a given location to utilize a health service can be estimated using a newly developed measure called the supply-concentric demand accumulation (SCDA) spatial availability index.
Kevin A. Matthews, Anne H. Gaglioti, James B. Holt, Anne G. Wheaton, Janet B. Croft   +4 more
doaj   +1 more source