Results 61 to 70 of about 12,079,078 (266)

Bali Folktale I Belog Oriented Towards Postmodernism to Increase Curiosity in Elementary School Students

Journal for Lesson and Learning Studies
The research problem focuses on the low level of curiosity among elementary school students and the limited availability of local culture-based learning resources as reading materials that can stimulate students' curiosity.
I Kadek Baladiva Anggarana, Putu Nanci Riastini, Ni Ketut Desia Tristiantari   +2 more
doaj   +1 more source

Quality Improvement in Teaching and Learning Science in Primary School Settings: Using a Metaphor to Approach the Concept of Light

Jurnal Ilmiah Pendidikan Fisika Al-Biruni, 2020
The present study focuses on the approach of the concept of light by primary school students. The study explores how a teaching procedure founded on using the metaphor that light travels as a wave reflects on the concept of light as a distinct natural ...
James Rodriguez, David Castro
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Tailoring inquiry for young scientists: investigating the impact of a DI PBL model on elementary students’ curiosity in biodiversity learning

Cogent Education
This study examined the impact of a Differentiated Instruction–Problem-Based Learning (DI–PBL) model on elementary students’ curiosity in biodiversity lessons.
Idam Ragil Widianto Atmojo, Dwi Yuniasih Saputri, Matsuri Matsuri, Roy Ardiansnyah, Fadhil Purnama Adi, Burhan   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mobile virtual reality for musical genre learning in primary education

Comput. Educ., 2019
Mobile virtual reality (VR) is increasingly becoming popular and accessible to everyone that holds a smartphone. In particular, digital didactics can take advantage of natural interaction and immersion in virtual environments, starting from primary ...
E. Innocenti, M. Geronazzo, Diego Vescovi, Rolf Nordahl, S. Serafin, L. Ludovico, F. Avanzini   +6 more
semanticscholar   +1 more source

Kahoot-Based Teams Games Tournament in Developing Students' Mathematical Critical Thinking

Profesi Pendidikan Dasar
Students’ low mathematical critical thinking skills, as shown by the 2022 PISA results and studies, suggest that traditional teaching methods may inadequately develop these abilities.
Lilik Mustofiyah, Sutama Sutama, Yulia Maftuhah Hidayati, Murfiah Dewi Wulandari   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source