Results 41 to 50 of about 1,820,902 (262)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Bali Folktale I Belog Oriented Towards Postmodernism to Increase Curiosity in Elementary School Students

Journal for Lesson and Learning Studies
The research problem focuses on the low level of curiosity among elementary school students and the limited availability of local culture-based learning resources as reading materials that can stimulate students' curiosity.
I Kadek Baladiva Anggarana, Putu Nanci Riastini, Ni Ketut Desia Tristiantari   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Tailoring inquiry for young scientists: investigating the impact of a DI PBL model on elementary students’ curiosity in biodiversity learning

Cogent Education
This study examined the impact of a Differentiated Instruction–Problem-Based Learning (DI–PBL) model on elementary students’ curiosity in biodiversity lessons.
Idam Ragil Widianto Atmojo, Dwi Yuniasih Saputri, Matsuri Matsuri, Roy Ardiansnyah, Fadhil Purnama Adi, Burhan   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Kahoot-Based Teams Games Tournament in Developing Students' Mathematical Critical Thinking

Profesi Pendidikan Dasar
Students’ low mathematical critical thinking skills, as shown by the 2022 PISA results and studies, suggest that traditional teaching methods may inadequately develop these abilities.
Lilik Mustofiyah, Sutama Sutama, Yulia Maftuhah Hidayati, Murfiah Dewi Wulandari   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

AUGMENTED REALITY MEDIA FOR LEARNING ELECTRICAL CIRCUITS: ENHANCING SCIENCE PROCESS SKILLS AND STUDENTS’ ACHIEVEMENT

Jurnal Eduscience
Purpose—The study aims to develop Android-based augmented reality (AR) instructional media for teaching electrical circuits, enhancing students' science process skills and learning outcomes.
Nendi Niati, Rahayu Condro Murti, Woro Sri Hastuti   +2 more
doaj   +1 more source