Results 201 to 210 of about 4,620,636 (276)

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor, Stefano Comai, Gianfranco Pasut, Franco Folli, Marco Gentilucci, Negar Gharavi, Sofia Raitsin, Thuy Van Nguyen, Marco Pappagallo, Andrea Mattarei, Paolo L. Manfredi, Sara De Martin   +11 more
wiley   +1 more source

Orexins and primary headaches: an overview of the neurobiology and clinical impact. [PDF]

Expert Rev Neurother
Stanyer EC, Hoffmann J, Holland PR.
europepmc   +1 more source

A scoping review of adverse events associated with concomitant beta‐adrenoreceptor blockers and selective serotonin reuptake inhibitors

British Journal of Clinical Pharmacology, EarlyView.
Beta‐adrenoreceptor blockers (beta‐blockers) and selective serotonin reuptake inhibitors (SSRIs) are commonly used medications and often used together, such as for the treatment of anxiety. However, there is no recent review of any potential adverse events related to concomitant use of medicines from each group.
Ziyi Cai, James Sutton, Charlotte Archer, Caroline S. Copeland, Joseph Hayes, Charles E. Leonard, Nicky Lidbetter, Kenneth K. C. Man, Faraz Mughal, Ian C. K. Wong, Hayley C. Gorton   +10 more
wiley   +1 more source

Children and adolescents with primary headaches exhibit altered sensory profiles - a multi-modal investigation. [PDF]

J Headache Pain
Pieniak M, Höfer B, Knipping J, Faria V, Richter M, Schriever VA, Haehner A, Gossrau G.   +7 more
europepmc   +1 more source

Systematic review of clinical trials and cohort studies evaluating HIV post‐exposure prophylaxis (PEP) regimens to inform updated Canadian guidelines

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background We conducted a systematic review of clinical trials and cohort studies on HIV post‐exposure prophylaxis (PEP) regimens to inform updated 2025 Canadian guidelines. Methods We searched Medline and Embase (July 2017–June 2024) for studies reporting on: HIV acquisition, PEP completion, adverse events (AEs) leading to discontinuation and/
Stanley O. Onyegbule, Maryam Habib, Rija Khalid, Jessie Tu, Deborah Yoong, Jaris Swidrovich, Wale Ajiboye, Patrick O'Byrne, Ameeta E. Singh, Jean‐Guy Baril, Tatiana Sotindjo, Mark W. Hull, Darrell H. S. Tan   +12 more
wiley   +1 more source

Intranasal administration of recombinant human BDNF as a potential therapy for some primary headaches. [PDF]

J Headache Pain
Greco R, Francavilla M, Facchetti S, Demartini C, Zanaboni AM, Antonangeli MI, Maffei M, Cattani F, Aramini A, Allegretti M, Tassorelli C, De Filippis L.   +11 more
europepmc   +1 more source

Pharmacokinetic and pharmacodynamic interaction of enavogliflozin, a sodium‐glucose cotransporter 2 inhibitor, with glimepiride and metformin in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Enavogliflozin, a sodium‐glucose cotransporter 2 inhibitor, is expected to be coadministered with antihyperglycaemic drugs with different mechanisms of action. This study aimed to investigate the pharmacokinetic (PK) and pharmacodynamic (PD) interactions between enavogliflozin, glimepiride and metformin.
Kyungrin Chang, Yoonjin Kim, Daye Jung, Jae Min Cho, Joo‐Youn Cho, SeungHwan Lee   +5 more
wiley   +1 more source

Listening to young children with disabilities: Experiences of quality in mainstream primary education

British Educational Research Journal, EarlyView.
Abstract All children should have access to quality education through a child‐centred pedagogy. An inclusive, child‐centred pedagogy uses a strength‐based view of children that recognises each child as unique and competent, providing children with multiple opportunities to explore and learn at their own pace.
Katherine Gulliver
wiley   +1 more source

Sex and age-related patterns in pediatric primary headaches: observations from an outpatient headache clinic. [PDF]

Front Neurol
Faria V, Höfer B, Klimova A, von der Hagen M, Berner R, Sabatowski R, Koch T, Hübler A, Richter M, Moulton EA, Holmes SA, Gossrau G.   +11 more
europepmc   +1 more source

International student agency in academic self‐formation: Mobility as agency situated within knowledge structures

British Educational Research Journal, EarlyView.
Abstract With growing attention to student agency in academic and policy discourse, international education has become a prominent context for examining how students navigate new cultural, academic, linguistic and social environments. However, much of this discussion attributes student agency to the ‘international’ aspect, while overlooking the ...
Soyoung Lee
wiley   +1 more source