Results 91 to 100 of about 4,403,696 (255)
Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
The promise of primary health care.
Bulletin of the World Health Organization, 2005 Twenty-seven years after it was embraced at Alma-Ata (now Almaty, Kazakhstan), primary health care and its call for “health for all” still holds a promise (1). Study of the history of medicine suggests its worldwide appeal. Primary health care is the latest expres-sion of a belief that can be traced to the 19th-century pathologist Rudolf Virchow: the ...
openaire +4 more sources
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Revitalising primary health care
Kathmandu University Medical Journal, 1970 doi: 10.3126/kumj.v6i3.1701Kathmandu University Medical Journal (2008), Vol. 6, No.
openaire +4 more sources
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Leprosy and Primary Health Care
Leprosy Review, 1982 If all goes well with the development of 'Health Care for All by the year 2000 ' , and current estimates of the prevalance of leprosy are approximately correct , and no dramatic changes take place in leprosy control technology , then we can expect that the number of leprosy patients under treatment will triple to about 1 2 million in the next 1 9 years
openaire +3 more sources
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source