Results 81 to 90 of about 5,361,490 (312)

Ease of access to general practice, patient experience and use of the NHS App: an ecological analysis of English data

JRSM Open
Summary Objective To assess the relationship between GP experience, phone and website access measures, and NHS App use. Design An ecological study using practice-level NHS App usage data between March 2020 and June 2022.
Sukriti KC, Chrysanthi Papoutsi, Claire Reidy, Bernard Gudgin, John Powell, Azeem Majeed, Felix Greaves, Anthony A Laverty   +7 more
doaj   +1 more source

Primary health care at the turn of the millennium : evolution, changes and contrasts [PDF]

, 2000
Primary health care is a form of front-line medicine comparable to a valve with a filter. If either is blocked or weak, large amounts of relatively unimportant and trivial material will overflow, causing confusion and delays in the secondary channels ...
Xuereb, Joseph
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Satisfaction and preference for home delivery pharmaceutical services among patients attending primary care settings in Qatar during COVID-19 pandemic: a cross-sectional study

BMJ Open
Objectives During the COVID-19 epidemic, due to the high risk associated with travel and group gatherings, the Ministry of Public Health in Qatar introduced home delivery of pharmaceutical services.
Ahmed Al Nuaimi, Muhammad Tanveer Alam, Shajitha Thekke Veettil, Jeyaram Illiayaraja Krishnan, Reena Ghazi Alsalmi, Jinsy Jacob, Aly Tamer Mousa, Samah Auni Mesbah Sakallah, Shafqat Mahmood   +8 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Prevalence and characterization of heart failure in Aragon, Spain (ICAR study)

Frontiers in Cardiovascular Medicine
IntroductionHeart failure (HF) imposes a significant clinical and care burden. The ICAR study sought to address the absence of recent population estimates and an integrated approach to the diagnosis of HF in Spain, specifically in the region of Aragon ...
Juan Carlos Romero-Vigara, Juan Carlos Romero-Vigara, Jose Ignacio González Lillo, David Bierge Valero, Patricia Arbués-Espinosa, Sandra Luz-Miguel, Jose Ramón Garcia-Solans, Irantzu Bengoa-Urrengoechea, Susana Larripa de la Natividad, Mónica Salazar González, Elisa Pilar Salazar González, Francisco Manuel Adán-Gil   +11 more
doaj   +1 more source

Can patients with low health literacy be identified from routine primary care health records? A cross-sectional and prospective analysis

BMC Family Practice, 2019
Background People with low health literacy (HL) are at increased risk of poor health outcomes, and receive less benefit from healthcare services. However, healthcare practitioners can effectively adapt healthcare information if they are aware of their ...
Paul Campbell, Martyn Lewis, Ying Chen, Rosie J. Lacey, Gillian Rowlands, Joanne Protheroe   +5 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source