Results 91 to 100 of about 5,361,490 (312)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Leprosy and Primary Health Care
Leprosy Review, 1982 If all goes well with the development of 'Health Care for All by the year 2000 ' , and current estimates of the prevalance of leprosy are approximately correct , and no dramatic changes take place in leprosy control technology , then we can expect that the number of leprosy patients under treatment will triple to about 1 2 million in the next 1 9 years
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Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Gout and subsequent erectile dysfunction: a population-based cohort study from England
Arthritis Research & Therapy, 2017 Background An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst gout patients are lacking.
Alyshah Abdul Sultan +6 more
doaj +1 more source
Primary Care Health Workforce in the United States [PDF]
, 2011 Synthesizes findings about trends in the composition, supply, and distribution of the primary care workforce; demand for and pressures on primary care providers; and the impact of technologies, payment policies, market forces, and scope of practice ...
Catherine Dower, Edward O
core
Revitalising primary health care
Kathmandu University Medical Journal, 1970 doi: 10.3126/kumj.v6i3.1701Kathmandu University Medical Journal (2008), Vol. 6, No.
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Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
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Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Neuroborreliosis in an immunosuppressed patient
Iberoamerican Journal of MedicineNeuroborreliosis is a rare but significant manifestation of Lyme disease, particularly in immunosuppressed individuals. We present the case of a 43-year-old patient with a history of follicular lymphoma in remission, currently undergoing maintenance ...
Alodia Rodríguez-Nájera +4 more
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