Results 101 to 110 of about 8,391,453 (340)

Will the Patient-Centered Medical Home Transform the Delivery of Health Care? [PDF]

, 2011
Explores various definitions of the medical home model, its components, rationale, effect on primary care, issues for implementation such as costs and payment methods, evidence of effectiveness, and healthcare reform provisions promoting ...
Kelly J. Devers, Rachel A. Burton, Robert A. Berenson   +2 more
core  

Job Burnout Among Primary Healthcare Workers in Rural China: A Multilevel Analysis

International Journal of Environmental Research and Public Health, 2020
The health workers in rural primary care systems are at the increasing risk of job burnout. To explore the prevalence and associated factors of the job burnout among the primary healthcare worker in rural China, a cross-sectional survey was conducted ...
Wanchun Xu, Zijing Pan, Zhong Li, Shan Lu, Liang Zhang   +4 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Improving Access to Adult Primary Care in Medicaid: Exploring the Potential Role of Nurse Practitioners and Physician Assistants [PDF]

, 2011
Provides an overview of the current supply, quality, and cost-effectiveness of nurse practitioners and physician assistants; new investments under the 2010 healthcare reform bill; and issues involved in meeting demand for primary care ...

core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Primary healthcare implementation in practice: Evidence from primary healthcare managers in Ghana

African Journal of Primary Health Care & Family Medicine, 2020
Contexte : Les soins de santé primaires (SSP) font partie intégrante des soins de santé dans les pays en développement. Cependant, la mise en œuvre des SSP depuis sa création dans les pays en développement a été léthargique, incohérente et entachée de controverses. Objectif : Cette étude examine certaines des controverses entourant la mise en œuvre des
openaire   +4 more sources

Physician Willingness and Resources to Serve More Medicaid Patients: Perspectives From Primary Care Physicians [PDF]

, 2011
Examines the characteristics of primary care physicians likely to accept new Medicaid patients when eligibility expands under the 2010 healthcare reform, including share of Medicaid patients and practice type and location.

core  

Early detection of communication delays with the PEDS tools in at-risk South African infants [PDF]

, 2016
Background: Prevalence of communication delays or disorders is increasing, possibly because of various environmental risk factors. Selection and implementation of effective screening tools are important to detect at-risk infants as early as possible ...
Glascoe, Frances Page, Hanekom, Linique, Lemmer, Tasha, Schoeman, Karla, Swanepoel, De Wet, van der Linde, Jeannie, Vinck, Bart   +6 more
core   +3 more sources

Do men avoid seeking medical advice? A register-based analysis of gender-specific changes in primary healthcare use after first hospitalisation at ages 60+ in Denmark

Journal of Epidemiology and Community Health, 2020
Background It remains unclear whether women’s greater primary healthcare use reflects a lower treatment-seeking threshold or a health disadvantage. We address this question by studying primary healthcare use surrounding a major health shock. Methods This
A. Höhn, J. Gampe, R. Lindahl-Jacobsen, K. Christensen, Anna Oksuyzan   +4 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source