Results 81 to 90 of about 7,197,157 (310)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

An integrative literature review of pre-registration nursing students' attitudes and perceptions towards primary healthcare

, 2019
Background: There is a renewed focus on the role of primary healthcare within the health system due to an ageing population, increasing cost of acute healthcare services, and an emphasis on developing healthier communities.
Byfield, Zachary, Conway, Jane, East, Leah   +2 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

St. Vincent's Healthcare Group annual review 2004 [PDF]

, 2005
St.
St. Vincent's Healthcare Group Ltd.
core  

Primary care and primary healthcare in obesity management

South African Medical Journal
RECOMMENDATIONS 1. We recommend that PHPs identify PLWO, and initiate patient-centred, health-focused conversations with them (Level 3, Grade C).2. We recommend that PHPs ensure that they ask PLWO for their permission prior to discussing weight or taking anthropometric measurements (Level 3, Grade C). 3.
P N Diab, Z Dire, J Hellig, M Conradie-Smit, W May   +4 more
openaire   +3 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

GP : general practitioner or general pragmatist? : the plight of management within primary healthcare

, 2012
Primary healthcare services hold an important role in Western healthcare systems. As the conduit to specialist and tertiary services, they can filter patient presentations, moderate patient-flow, and improve resource-use.
Dadich, Ann M. (R10177)
core  

St. Vincent's Healthcare Group annual review 2003 [PDF]

, 2004
St.
St. Vincent's Healthcare Group Ltd.
core  

Healthcare personnel's experiences using video consultation in primary healthcare in rural areas

, 2017
Background Patients living in rural areas often need to travel long distances for access to specialist care. To increase access to specialist care, video consultation between patients in primary healthcare and specialist care has been used.
Söderberg, Siv, Johansson, Annette,, Söderberg, Siv,, Lindberg, Inger,, Johansson, Annette, Lindberg, Inger   +5 more
core   +1 more source