Results 91 to 100 of about 7,197,157 (310)

Selection of optimal revascularization tactics in patients with polyvascular disease: a literature review

Российский кардиологический журнал
Patients with polyvascular disease (PVD), involving two or more vascular beds, are a difficult group for cardiologists, cardiovascular surgeons and endovascular surgeons. The relevance of the problem is due to its widespread prevalence, rapid progression,
T. I. Gaigiev, G. M. Kostanyan, N. A. Nikolaev   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Implementing continuous glucose monitoring in public primary care for type 2 diabetes management: a convergent mixed-methods study of patient and provider experiences in Singapore

BMC Primary Care
Background Type 2 diabetes (T2D) is highly prevalent in Singapore, yet glycemic control remains suboptimal in primary care. Continuous glucose monitoring (CGM) offers real-time feedback that may improve self-management, but adoption in Asian primary care
Shilpa Tyagi, Keith Sng, David Wei Liang Ng, Valerie Hui Ying Teo, Si Min Thio, Jeremy Cong En He, Chun Yen Beh, Ming Hann Cheah, Nooradlin Marina Binti Mohammad Junaidi See Toh, Jiawei Chen, Gerald Choon-Huat Koh   +10 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Undermining India’s primary healthcare missions [PDF]

India’s Budget 2026–27 was presented on February 1 with much celebration and described as a transformative step toward inclusive growth. Finance Minister Nirmala Sitharaman reiterated the government’s commitment to ensuring access to resources and ...
Thakur, Avanindra Nath, Bajpayee, Kaushalya   +1 more
core  

Physicians’ experiences of assessing and supporting fatigued patients in primary care: a focus group study

BMC Primary Care
Background Fatigue is a common symptom in primary healthcare, affecting 10–30% of patients, and is associated with increased healthcare consumption and functional disability.
Conrad Samuelsson, Lisa Gunnarsson, Frank Svärdman, Christian Rück, Elin Lindsäter   +4 more
doaj   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Characteristics of primary healthcare providers.

, 2022
Characteristics of primary healthcare providers.
Faugia Islam Anne (14259489), Deborah Ash (14259504), Sifat Parveen Sheikh (14259495), Kristen Kappos (14259501), Syeda Mahsina Akter (14259492), Sabrina Rasheed (655672), Santhia Ireen (5077898), Jessica Escobar-DeMarco (14259498)   +7 more
core   +1 more source

Barriers and enablers to using evidence-based antibiotic prescription guidelines in primary care: a qualitative systematic review and synthesis using the theoretical domains framework

Implementation Science Communications
Background Antibiotics are commonly overprescribed for upper respiratory tract infections (URTIs) in primary care against widely known guideline recommendations. To design an effective intervention to improve adherence to URTI guideline-based care, it is
Krystal Bursey, Andrea M. Patey, Holly Etchegary, Kris Aubrey-Bassler, Victoria Kavanagh, Andrea Pike, Kristen Romme, Jeremy M. Grimshaw, Amanda Hall   +8 more
doaj   +1 more source

Addressing low-value pharmacological prescribing in primary prevention of CVD through a structured evidence-based and theory-informed process for the design and testing of de-implementation strategies: the DE-imFAR study

Implementation Science, 2020
Background De-implementation or abandonment of ineffective or low-value healthcare is becoming a priority research field globally due to the growing empirical evidence of the high prevalence of such care and its impact in terms of patient safety and ...
Alvaro Sanchez, Jose Ignacio Pijoan, Susana Pablo, Marta Mediavilla, Rita Sainz de Rozas, Itxasne Lekue, Susana Gonzalez-Larragan, Gaspar Lantaron, Jon Argote, Arturo García-Álvarez, Pedro Maria Latorre, Christian D. Helfrich, Gonzalo Grandes   +12 more
doaj   +1 more source