Results 101 to 110 of about 7,197,157 (310)

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Homecare workers - an untapped resource in preventing emergency department visits among older individuals? A qualitative interview study from Sweden

BMC Geriatrics
Background Older individuals with functional decline and homecare are frequent visitors to emergency departments (ED). Homecare workers (HCWs) interact regularly with their clients and may play a crucial role in their well-being.
Pia Bastholm-Rahmner, Monica Bergqvist, Karin Modig, Lars L. Gustafsson, Katharina Schmidt-Mende   +4 more
doaj   +1 more source

Isolated Hypogonadotropic Hypogonadism in a Young Woman with Primary Amenorrhoea

Oman Medical Journal
We describe a case of a young woman who presented with delayed secondary sexual development and primary amenorrhoea. She had low levels of oestradiol, follicle-stimulating hormone, and luteinizing hormone with normal levels of other pituitary hormones ...
Zalkha Al Kharusi, Nadia Al Mabaihsi, Amani Al Rawahi, Abeer Al Hadhrami, Maisa Al Kiyumi, Almundher Al-Maawali, Abdulaziz Al Mahrezi   +6 more
doaj   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Primary healthcare has a central role in addressing global sustainable goals

, 2020
The Sustainable Development Solutions Network (SDSN) (2019) states that universities play a vital role in addressing global challenges and achieving the Sustainable Development Goals (SDSN 2019).
Smith, Ana (R8601), Dixon, Kathleen A. (R7595), McDermid, Fiona (R16858)   +2 more
core  

Potential for patients and community level medical practitioners to influence high technology healthcare: evidence from Perth, Western Australia [PDF]

, 2007
Evidence is presented from a Case Study of the Inquiry into King Edward Memorial Hospital, a tertiary level maternity hospital in Perth, Western Australia, that values of medical professionalism can be distorted and contribute to impaired standards of ...
Thomas, Terrance
core  

Facilitators and Barriers to Scaling-Up Integrated Care for Arterial Hypertension and Type 2 Diabetes in Slovenia: Qualitative Study

Slovenian Journal of Public Health
Arterial hypertension and type 2 diabetes are significant contributors to global non-communicable disease-related mortality. Integrated care, centred on person-centred principles, aims to enhance healthcare quality and access, especially for vulnerable ...
ZAVRNIK Črt, STOJNIĆ Nataša, MORI LUKANČIČ Majda, MIHEVC Matic, VIRTIČ POTOČNIK Tina, KLEMENC-KETIŠ Zalika, POPLAS SUSIČ Antonija   +6 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Management of gout in primary care of Hong Kong in accordance with international guidelines: any gaps to bridge?

BMC Primary Care
Background The global prevalence of gout ranges from 1 to 6.8% in different countries, while around 3% in Hong Kong. Sudden elevated serum urate level (SUA) will result in acute arthritis and repeated flare-ups.
Kamsheung Chan, Lapkin Chiang, Ken Kaming Ho, Yimchu Li, SH Ko, Catherine Xiaorui Chen   +5 more
doaj   +1 more source