Results 61 to 70 of about 1,515,766 (316)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Healthcare disparities and models for change. [PDF]

, 2004
With Healthy People 2010 making the goal of eliminating health disparities a national priority, policymakers, researchers, medical centers, managed care organizations (MCOs), and advocacy organizations have been called on to move beyond the historic ...
Bengen-Seltzer, Barbara, Baquet, Claudia R, Carter-Pokras, Olivia   +2 more
core   +1 more source

Sustainability of healthcare professionals’ adherence to clinical practice guidelines in primary care [PDF]

, 2022
: Background: Sustainability of adherence to clinical practice guidelines (CPGs) represents an important indicator of the successful implementation in the primary care setting.
Stewart, Simon, Polotan, Mary Janice, Zhao, Isabella, Eliseeva, Sabina, Tan, Jing‑Yu, Wang, Tao, Chan, Raymond J, Liu, Xian-Liang, Tan, Jing-Yu, Chan, Raymond J.   +9 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Challenge and the Importance of Primary Healthcare

, 2020
A wealth of evidence shows that primary healthcare (PHC) can provide healthcare in a more affordable, equitable, efficient, and cost-effective way and improve health outcomes.
Luk, Sabrina Ching Yuen, Sabrina Ching Yuen Luk   +1 more
core   +1 more source

Primary healthcare implementation in practice: Evidence from primary healthcare managers in Ghana

African Journal of Primary Health Care & Family Medicine, 2020
Contexte : Les soins de santé primaires (SSP) font partie intégrante des soins de santé dans les pays en développement. Cependant, la mise en œuvre des SSP depuis sa création dans les pays en développement a été léthargique, incohérente et entachée de controverses. Objectif : Cette étude examine certaines des controverses entourant la mise en œuvre des
openaire   +4 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

National Analyses on Survival in Maltese Adult Patients on Renal Replacement Therapy Started During 2009–2012

European Medical Journal, 2019
Chronic kidney disease patients on maintenance dialysis (CKD 5D) experience major morbidity and mortality. No data on survival in Maltese dialysis patients exist; therefore, the aim of this study was to rigorously examine survival statistics in a ...
Baldacchino Ian, Debattista Sarah, Debattista Daniel, Balzan Gabriella, Abdilla Stefania, Baldacchino Lisa, Borg Gabriel, Buttigieg Sacha, Calleja Stafrace Nadine, Cutajar Karl, Galea Marica, Sciberras Whitney, Xerri Thelma, Camilleri Liberato, Farrugia Emanuel   +14 more
doaj  

A qualitative study of health worker experiences navigating dual financing streams of statutory and project-based funding in Nigerian primary health centres

Discover Public Health
Background Nigeria’s Basic Health Care Provision Fund (BHCPF) and project-based Direct Facility Financing (DFF) often operate concurrently in primary health care facilities.
Olamide Akeboi, David Bassey, Marvellous Oni, Aderonke Sule-Odu, Oluwaseun Oladoye, Godwin Idim, Obiageli Onwusaka, Michael Oguntoye, Osoko Oluyemi, Muideen Olatunji, Nnenna Oji, Ifeoma Ezenyi, Dupsy Akoma, Fayokemi Olususi, Abisoye Oyeyemi, Nusirat Elelu, Oluwole Odutolu, Chijioke Kaduru   +17 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source