Results 61 to 70 of about 6,782,722 (310)

A qualitative study of health worker experiences navigating dual financing streams of statutory and project-based funding in Nigerian primary health centres

Discover Public Health
Background Nigeria’s Basic Health Care Provision Fund (BHCPF) and project-based Direct Facility Financing (DFF) often operate concurrently in primary health care facilities.
Olamide Akeboi, David Bassey, Marvellous Oni, Aderonke Sule-Odu, Oluwaseun Oladoye, Godwin Idim, Obiageli Onwusaka, Michael Oguntoye, Osoko Oluyemi, Muideen Olatunji, Nnenna Oji, Ifeoma Ezenyi, Dupsy Akoma, Fayokemi Olususi, Abisoye Oyeyemi, Nusirat Elelu, Oluwole Odutolu, Chijioke Kaduru   +17 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Analysis of Primary Healthcare Indicators

Mathematical and Computational Applications
This study aims to analyze the relationships between various health indicators, using an exploratory graph analysis, repeated measures correlation, and cluster construction. Primary healthcare is essential for providing continuous and comprehensive care, with indicators as crucial tools to identify and improve weaknesses in health units.
Ana Leonor Saraiva, Cristiana J. Silva, Jorge Cabral, José Pedro Antunes, Paula Rama, Sofia J. Pinheiro, Vera Afreixo   +6 more
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Implementing continuous glucose monitoring in public primary care for type 2 diabetes management: a convergent mixed-methods study of patient and provider experiences in Singapore

BMC Primary Care
Background Type 2 diabetes (T2D) is highly prevalent in Singapore, yet glycemic control remains suboptimal in primary care. Continuous glucose monitoring (CGM) offers real-time feedback that may improve self-management, but adoption in Asian primary care
Shilpa Tyagi, Keith Sng, David Wei Liang Ng, Valerie Hui Ying Teo, Si Min Thio, Jeremy Cong En He, Chun Yen Beh, Ming Hann Cheah, Nooradlin Marina Binti Mohammad Junaidi See Toh, Jiawei Chen, Gerald Choon-Huat Koh   +10 more
doaj   +1 more source

Primary care and primary healthcare in obesity management

South African Medical Journal
RECOMMENDATIONS 1. We recommend that PHPs identify PLWO, and initiate patient-centred, health-focused conversations with them (Level 3, Grade C).2. We recommend that PHPs ensure that they ask PLWO for their permission prior to discussing weight or taking anthropometric measurements (Level 3, Grade C). 3.
P N Diab, Z Dire, J Hellig, M Conradie-Smit, W May   +4 more
openaire   +3 more sources