Results 51 to 60 of about 6,782,722 (310)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Primary Healthcare: A ‘Jigsaw’ In Reform of the Health Services [PDF]

, 2011
Health service reform is on the policy agenda throughout the world.Since the Declaration of Alma-Ata in 1978, much of the discussionabout the role of primary healthcare (PHC) in health service reformhas centred on the political attraction to ...
Regmi, Krishna
core  

Pap smear participation rates, primary healthcare and Indigenous women [PDF]

, 2003
To the Editor: As practitioners in a community-controlled Aboriginal and Torres Strait Islander primary healthcare centre, striving to better meet the healthcare needs of our community, we would like to offer some thoughts on a recent article by Coory et
Panaretto, Katie S., Manessis, Vivienne, Larkins, Sarah   +2 more
core   +1 more source

Diagnosis of right bundle branch block: a concordance study

BMC Family Practice, 2019
Background Right bundle branch block is one of the most common electrocardiographic abnormalities. Most cases of right bundle branch block are detected in asymptomatic patients in primary care, so a correct interpretation of electrocardiograms (ECGs) at ...
M. Alventosa-Zaidin, G. Pera, C. Roca Saumell, N. Mengual Miralles, M. V. Zamora Sanchez, T. Gros Garcia, L. Guix Font, M. Benitez Camps, J. Francisco-Pascual, J. Brugada Terradellas   +9 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Primary healthcare implementation in practice: Evidence from primary healthcare managers in Ghana

African Journal of Primary Health Care & Family Medicine, 2020
Contexte : Les soins de santé primaires (SSP) font partie intégrante des soins de santé dans les pays en développement. Cependant, la mise en œuvre des SSP depuis sa création dans les pays en développement a été léthargique, incohérente et entachée de controverses. Objectif : Cette étude examine certaines des controverses entourant la mise en œuvre des
openaire   +4 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Development of a primary care-based complex care management intervention for chronically ill patients at high risk for hospitalization: a study protocol [PDF]

, 2010
Background: Complex care management is seen as an approach to face the challenges of an ageing society with increasing numbers of patients with complex care needs.
Gerlach, Ferdinand M., Joachim Szecsenyi, Beyer Martin, Szecsenyi, Joachim, Freund, T., Gerlach Ferdinand M, Peters-Klimm Frank, Ferdinand M Gerlach, Peters-Klimm, Frank, Erler, Antje, Cornelia Mahler, Gensichen Jochen, Peters-Klimm, F., Mahler Cornelia, Beyer, M., Freund, Tobias, Wensing Michel, Martin Beyer, Wensing, M.J.P., Michel Wensing, Antje Erler, Erler, A., Szecsenyi Joachim, Gensichen, Jochen, Szecsenyi, J., Freund Tobias, Beyer, Martin, Mahler, Cornelia, Gerlach, F.M., Tobias Freund, Wensing, Michel, Jochen Gensichen, Frank Peters-Klimm, Mahler, C., Gensichen, J., Erler Antje   +35 more
core   +2 more sources

National Analyses on Survival in Maltese Adult Patients on Renal Replacement Therapy Started During 2009–2012

European Medical Journal, 2019
Chronic kidney disease patients on maintenance dialysis (CKD 5D) experience major morbidity and mortality. No data on survival in Maltese dialysis patients exist; therefore, the aim of this study was to rigorously examine survival statistics in a ...
Baldacchino Ian, Debattista Sarah, Debattista Daniel, Balzan Gabriella, Abdilla Stefania, Baldacchino Lisa, Borg Gabriel, Buttigieg Sacha, Calleja Stafrace Nadine, Cutajar Karl, Galea Marica, Sciberras Whitney, Xerri Thelma, Camilleri Liberato, Farrugia Emanuel   +14 more
doaj