Results 51 to 60 of about 1,515,766 (316)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Primary Healthcare: A ‘Jigsaw’ In Reform of the Health Services [PDF]

, 2011
Health service reform is on the policy agenda throughout the world.Since the Declaration of Alma-Ata in 1978, much of the discussionabout the role of primary healthcare (PHC) in health service reformhas centred on the political attraction to ...
Regmi, Krishna
core  

Prevalence and Forms of Workplace Bullying Among Health-care Professionals in Cyprus: Greek Version of “Leymann Inventory of Psychological Terror” Instrument

Safety and Health at Work, 2018
Background: Workplace bulling is a pervasive phenomenon with negative consequences for the health of victims and the productivity of organizations.
Theodora Zachariadou, Savvas Zannetos, Stella Elia Chira, Sofia Gregoriou, Andreas Pavlakis   +4 more
doaj   +1 more source

High self-efficacy – a predictor of reduced pain and higher levels of physical activity among patients with osteoarthritis: an observational study

BMC Musculoskeletal Disorders, 2020
Background Self-efficacy is considered a core component in self-management. However, there is a lack of knowledge about the association between self-efficacy and health-related outcomes in osteoarthritis.
Åsa Degerstedt, Hassan Alinaghizadeh, Carina A. Thorstensson, Christina B. Olsson   +3 more
doaj   +1 more source

Measuring in-hospital quality multidimensionally by integrating patients’, kin’s and healthcare professionals’ perspectives: development and validation of the FlaQuM-Quickscan

BMC Health Services Research, 2023
Background Measuring quality is essential to drive improvement initiatives in hospitals. An instrument that measures healthcare quality multidimensionally and integrates patients’, kin’s and professionals’ perspectives is lacking. We aimed to develop and
Fien Claessens, Deborah Seys, Charlotte Van der Auwera, Anneke Jans, Eva Marie Castro, Laura Jacobs, Dirk De Ridder, Luk Bruyneel, Zita Leenaerts, Astrid Van Wilder, Jonas Brouwers, Peter Lachman, Kris Vanhaecht, The FlaQuM Research Group   +13 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Developing Primary Care: The Contribution of Primary Care Research Networks [PDF]

, 2012
The performance of Canada's primary care sector remains lacklustre relative to other wealthy industrialized countries, and it has been suggested that a lack of investment in research and evaluation may be a cause. One approach to improving and sustaining
Peckham, Stephen, Hutchison, Brian, Hutchinson, Brian   +2 more
core   +1 more source

Assessing the prevalence of non-communicable diseases and their modifiable risk factors in primary healthcare: retrospective analysis of annual health screening in the United Arab Emirates

BMJ Open
Objectives Non-communicable diseases (NCDs) and their associated risk factors are becoming increasingly prevalent worldwide. NCDs are both a health burden and an economic burden, but many can be prevented by public health interventions that include ...
Hayfa Hamad Al Ali, Aisha Suhail, Micha Gerard Constant Bouts, Fatima Al Meleh, Kareemah Al Raeesi   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Diagnosis of right bundle branch block: a concordance study

BMC Family Practice, 2019
Background Right bundle branch block is one of the most common electrocardiographic abnormalities. Most cases of right bundle branch block are detected in asymptomatic patients in primary care, so a correct interpretation of electrocardiograms (ECGs) at ...
M. Alventosa-Zaidin, G. Pera, C. Roca Saumell, N. Mengual Miralles, M. V. Zamora Sanchez, T. Gros Garcia, L. Guix Font, M. Benitez Camps, J. Francisco-Pascual, J. Brugada Terradellas   +9 more
doaj   +1 more source