Results 41 to 50 of about 2,532,218 (312)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Prevalence and Forms of Workplace Bullying Among Health-care Professionals in Cyprus: Greek Version of “Leymann Inventory of Psychological Terror” Instrument

Safety and Health at Work, 2018
Background: Workplace bulling is a pervasive phenomenon with negative consequences for the health of victims and the productivity of organizations.
Theodora Zachariadou, Savvas Zannetos, Stella Elia Chira, Sofia Gregoriou, Andreas Pavlakis   +4 more
doaj   +1 more source

High self-efficacy – a predictor of reduced pain and higher levels of physical activity among patients with osteoarthritis: an observational study

BMC Musculoskeletal Disorders, 2020
Background Self-efficacy is considered a core component in self-management. However, there is a lack of knowledge about the association between self-efficacy and health-related outcomes in osteoarthritis.
Åsa Degerstedt, Hassan Alinaghizadeh, Carina A. Thorstensson, Christina B. Olsson   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Assessing the prevalence of non-communicable diseases and their modifiable risk factors in primary healthcare: retrospective analysis of annual health screening in the United Arab Emirates

BMJ Open
Objectives Non-communicable diseases (NCDs) and their associated risk factors are becoming increasingly prevalent worldwide. NCDs are both a health burden and an economic burden, but many can be prevented by public health interventions that include ...
Hayfa Hamad Al Ali, Aisha Suhail, Micha Gerard Constant Bouts, Fatima Al Meleh, Kareemah Al Raeesi   +4 more
doaj   +1 more source

Direct healthcare costs of diabetes mellitus patients in Spain [PDF]

, 2003
Objectives. To estimate the healthcare resources spent by diabetic patients in Spain during the year 2002. Methods. The present work is a cost-of-illness study.
Lobo, Félix, Molina, Begoña, Monereo, Susana, Oliva Moreno, Juan   +3 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Re-engineering primary healthcare in Kerala

Public Health Action, 2023
<sec> <title>INTRODUCTION:</title> In the backdrop of the Sustainable Development Goals (SDGs), the state of Kerala, India, revamped its existing primary health centres (PHCs) into people-friendly family health centres (FHCs) in order to provide comprehensive primary care as part of a mission-based (‘Aardram’) initiative.
A, Krishnan, R P, Varma, R, Kamala, R, Anju, K, Vijayakumar, R, Sadanandan, P K, Jameela, K S, Shinu, B, Soman, R M, Ravindran   +9 more
openaire   +2 more sources

Exploring Patient Satisfaction among Transgender and Non-Binary Identified Healthcare Users: The Role of Microaggressions and Inclusive Healthcare Settings [PDF]

, 2018
Patient satisfaction is an important indicator of quality of healthcare delivery. Transgender and non-binary (TGNB) people regularly report experiencing discrimination when in healthcare settings and few TGNB-inclusive services are available. Researchers
Forbes-Roberts, Stevie
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source