Results 71 to 80 of about 7,704 (220)

Opportunities in Primary and Enteric Hyperoxaluria at the Cross-Roads Between the Clinic and Laboratory

Kidney International Reports
Hyperoxaluria is a condition in which there is a pathologic abundance of oxalate in the urine through either hepatic overproduction (primary hyperoxaluria [PH]) or excessive enteric absorption of dietary oxalate (enteric hyperoxaluria [EH]). Severity can
Barbara Cellini, Michelle A. Baum, Yaacov Frishberg, Jaap W. Groothoff, Peter C. Harris, Sally A. Hulton, Felix Knauf, John Knight, John C. Lieske, W. Todd Lowther, Shabbir Moochhala, Lama Nazzal, Gregory E. Tasian, Jonathan M. Whittamore, David J. Sas   +14 more
doaj   +1 more source

ヒト肝におけるセリン：グリオキシル酸変換酵素活性によるアラニン：グリオキシル酸変換酵素の測定 [PDF]

, 2010
浜松医科大学学位論文　医博論第479号 ...
7462, 永田, 仁夫
core   +2 more sources

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, Volume 22, Issue 16, 17 March 2026.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Testing the role of predicted gene knockouts in human anthropometric trait variation [PDF]

, 2014
National Heart, Lung, and Blood Institute (NHLBI) S.L. is funded by a Canadian Institutes of Health Research Banting doctoral scholarship. G.L. is funded by Genome Canada and Génome Québec; the Canada Research Chairs program; and the Montreal Heart ...
Lessard, S, Manning, AK, Low-Kam, C, Auer, PL, Giri, A, Graff, M, Schurmann, C, Yaghootkar, H, Luan, J, Esko, T, Karaderi, T, Bottinger, EP, Lu, Y, Carlson, C, Caulfield, M, Dube, M-P, Jackson, RD, Kooperberg, C, McKnight, B, Mongrain, I, Peters, U, Reiner, AP, Rhainds, D, Sotoodehnia, N, Hirschhorn, JN, Scott, RA, Munroe, PB, Frayling, TM, Loos, RJF, North, KE, Edwards, TL, Tardif, J-C, Lindgren, CM, Lettre, G, Project, NHLBIGES, GOT2D, T2D-GENES, Consortium, GIANT   +37 more
core   +3 more sources

The intestine and the kidneys : a bad marriage can be hazardous [PDF]

, 2015
The concept that the intestine and chronic kidney disease influence each other, emerged only recently. The problem is multifaceted and bidirectional. On one hand, the composition of the intestinal microbiota impacts uraemic retention solute production ...
Glorieux, Griet, Vanholder, Raymond
core   +1 more source

Does instrumentation and irrigation configuration affect intrarenal pressure during PCNL?

BJUI Compass, Volume 7, Issue 2, February 2026.
Abstract Objectives To measure the effects of varying configurations of nephroscope sheath, irrigation, instruments, and suction on intrarenal pressure (IRP) during percutaneous nephrolithotomy (PCNL). Materials and Methods Kidney and ureter 3D printed models from a deidentified patient's CT scan were placed in a plaster and foam mould, simulating the ...
Evan Seibly, Ali Albaghli, Kyu Park, Elizabeth A. Baldwin, Ala'a Farkouh, Katya Hanessian, Nicole Mack, Cliff De Guzman, Toby Clark, Matthew Buell, Rose Leu, Kanha Shete, Sikai Song, Akin S. Amasyali, Zham Okhunov, D. Duane Baldwin   +15 more
wiley   +1 more source

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

Gut microbiota modulation via fecal microbiota transplantation mitigates hyperoxaluria and calcium oxalate crystal depositions induced by high oxalate diet

Gut Microbes
Hyperoxaluria, including primary and secondary hyperoxaluria, is a disorder characterized by increased urinary oxalate excretion and could lead to recurrent calcium oxalate kidney stones, nephrocalcinosis and eventually end stage renal disease.
Lingyue An, Shujue Li, Zhenglin Chang, Min Lei, Zhican He, Peng Xu, Shike Zhang, Zheng Jiang, Muhammad Sarfaraz Iqbal, Xinyuan Sun, Hongxing Liu, Xiaolu Duan, Wenqi Wu   +12 more
doaj   +1 more source

Primary hyperoxaluria type 1 in Tunisian children

Saudi Journal of Kidney Diseases and Transplantation, 2012
To determine the clinical, biological, and radiological futures of primary hyper-oxaluria type 1 in Tunisian children, we retrospectively studied 44 children with primary hyper-oxaluria type 1 who were treated in our center from 1995 to 2009.
Tahar Gargah, Nourchene Khelil, Gharbi Youssef, Wiem Karoui, Mohamed Rachid Lakhoua, Jaouida Abdelmoula   +5 more
doaj   +1 more source

Vitamin B6 metabolites in idiopathic calcium stone formers: no evidence for a link to hyperoxaluria [PDF]

, 2018
Vitamin B6 metabolites and their potential correlates to urinary oxalate excretion in idiopathic calcium stone formers (ICSF) compared with healthy subjects were investigated.
Casez, Jean-Paul, Jaeger, Philippe, Kaelin, Agnes   +2 more
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