Results 101 to 110 of about 728,195 (307)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Proper Fuzzification of Prime Ideals of a Hemiring

Advances in Fuzzy Systems, 2012
Prime fuzzy ideals, prime fuzzy k-ideals, and prime fuzzy h-ideals are roped in one condition. It is shown that this way better fuzzification is achieved. Other major results of the paper are: every fuzzy ideal (resp., k-ideal, h-ideal) is contained in a
H. V. Kumbhojkar
doaj   +1 more source

The Rough Intuitionistic Fuzzy Ideals of Intuitionistic Fuzzy Subrings in a Commutative Ring

Fuzzy Information and Engineering, 2014
The aim of this paper is to give some definitions of rough intuitionistic fuzzy ideal, rough intuitionistic fuzzy radical, rough prime (primary) intuitionistic fuzzy ideal and rough semiprime intuitionistic fuzzy ideal of an intuitionistic fuzzy subring,
Prasenjit Mandal, A.S. Ranadive
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Perception of Primary School Students On Ideal Teacher [PDF]

, 2015
Bu araştırmanın amacı, ilköğretim öğrencilerinin ideal öğretmenin sahip olması gereken özelliklerine ilişkin algılarını belirlemektir. Tarama modeli benimsenerek gerçekleştirilen araştırmanın katılımcılarını, 2010-2011 öğretim yılında Eskişehir Milli ...
Gültekin, Mehmet
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Bullying Roles in Changing Contexts: The Stability of Victim and Bully Roles from Primary to Secondary School [PDF]

, 2004
The present study was conducted to predict bullying roles over a six years time period and across contexts differing in the degree of peer hierarchies.
Dieter Wolke, Korn, Stefan, Mechthild Schäfer, Brodbeck, Felix C., Wolke, Dieter, Schafer, M., Henrike Schulz, Schulz, Henrike, Schäfer, Mechthild, Stefan Korn, Felix C. Brodbeck   +10 more
core   +1 more source

Primary Decomposition of Symmetric Ideals

CoRR
We propose an effective method for primary decomposition of symmetric ideals. Let $K[X]=K[x_1,\ldots,x_n]$ be the $n$-valuables polynomial ring over a field $K$ and $\mathfrak{S}_n$ the symmetric group of order $n$. We consider the canonical action of $\mathfrak{S}_n$ on $K[X]$ i.e. $σ(f(x_1,\ldots,x_n))=f(x_{σ(1)},\ldots,x_{σ(n)})$ for $σ\in \mathfrak{
openaire   +3 more sources

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source