Results 41 to 50 of about 725,736 (307)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

The critical components of an electronic care plan tool for primary care: an exploratory qualitative study

open access: yes, 2016
Background A critical need exists for effective electronic tools that facilitate multidisciplinary care for complex patients in patient-centered medical homes.
Adrian Zai   +11 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Cellular Binomial Ideals. Primary Decomposition of Binomial Ideals

open access: yesJournal of Symbolic Computation, 2000
In addition to the work of \textit{D. Eisenbud} and \textit{B. Sturmfels} [Duke Math. J. 84, 1-45 (1996; Zbl 0873.13021)], the authors present more detailed algorithms for the binomial primary decomposition of a binomial ideal in the ring of polynomials \(K[x_1,x_2, \dots,x_n]\) over an algebraically closed field \(K\). In so doing, decompositions into
Ignacio Ojeda Martínez de Castilla   +1 more
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Primary ideal theory for quadratic Jordan algebras

open access: yes, 1973
The notion of a primary ideal was originally introduced in the study of noetherian rings, i.e., commutative associative rings with unity which have the maximum condition on ideals. In more recent years, this notion has been carried over to noncommutative
Foster, D, Tsai, C
core   +1 more source

The Structure of Neutrosophic Radical of an ideal and Primary Ideal in Neutrosophic Rings [PDF]

open access: yesNeutrosophic Sets and Systems
In this study, we define radical and primary ideals as novel types of neutrosophic substructures within a neutrosophic ring. We investigate the properties of these substructures based on the characteristics of neutrosophic rings.
Murhaf Riad Alabdullah
doaj   +1 more source

Energetic Co-Crystal of a Primary Metal-Free Explosive with BTF. Ideal Pair for Co-Crystallization

open access: yesMolecules, 2021
Co-crystallization is an elegant technique to tune the physical properties of crystalline solids. In the field of energetic materials, co-crystallization is currently playing an important role in the engineering of crystals with improved performance ...
Kyrill Yu. Suponitsky   +6 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

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