Results 61 to 70 of about 2,642,513 (283)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The Ideal Primary School Teacher
Social Behavior and Personality: an international journal, 2011 The qualities that an ideal primary school teacher has to have according to the view of 109 teacher trainees were investigated. Data were collected from an open-ended question in which the participants' views about the ideal primary school teacher and the reasoning behind those views were explored.
openaire +5 more sources
Human Resources for Health, 2017 Background The purpose of this study was to estimate the gap between the available and the ideal supply of human resources (physicians, nurses, and health promoters) to deliver the guaranteed package of prevention and health promotion services at urban ...
Jacqueline Elizabeth Alcalde-Rabanal +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Iterated socles and integral dependence in regular rings [PDF]
, 2014 Let $R$ be a formal power series ring over a field, with maximal ideal $\mathfrak m$, and let $I$ be an ideal of $R$ such that $R/I$ is Artinian. We study the iterated socles of $I$, that is the ideals which are defined as the largest ideal $J$ with $J ...
Corso, Alberto +4 more
core
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Primary Capacities of Meaning and Ideal
The Global PsychotherapistThis article continues a four-part series that refines the list, definitions, and diagnostic criteria of the primary actual capacities proposed by Nossrat Peseschkian, integrating them with contemporary psychodynamic theory and practice.
Ivan Kirillov
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
A formula for the *-core of an ideal [PDF]
, 2009 Expanding on the work of Fouli and Vassilev \cite{FV}, we determine a formula for the *-$\rm{core}$ of an ideal in two different settings: (1) in a Cohen--Macaulay local ring of characteristic $p>0$, perfect residue field and test ideal of depth at least
Adela +3 more
core
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source