Results 61 to 70 of about 890,728 (306)

Clinicopathological Significance of Poorly Differentiated Clusters in Liver Metastatic Lesions of Colorectal Carcinoma

Zhongliu Fangzhi Yanjiu, 2022
Objective To investigate the clinicopathological significance of PDC in liver metastases and analyze the correlation of PDC between liver metastases and primary lesions.
PENG Hui, ZHANG Zhifa, WU Yingjun, ZHANG Xiaohan, ZHU Xianqiang, QIN Haili   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Modules identification in gene positive networks of hepatocellular carcinoma using pearson agglomerative method and Pearson cohesion coupling modularity [PDF]

, 2012
In this study, a gene positive network is proposed based on a weighted undirected graph, where the weight represents the positive correlation of the genes.
Hu, Jinyu, Zhiwei Gao, Jinyu Hu, Gao, Zhiwei   +3 more
core   +1 more source

miRNA biomarkers in colon cancer liver metastasis: a preliminary analysis

结直肠肛门外科, 2022
[Objectives] To identify miRNAs associated with colon cancer liver metastasis and their influences on survival. [Methods] The study compared the miRNAs data sets of primary colon cancer tissues and liver metastasis tissues from colon cancer patients with
Fu Tianhao, Liao Xiwen, Zhou Xin, Wang Xiangkun, Liu Junqi, Wei Zhongliu, Zhu Guangzhi, Gong Yizhen, Peng Tao   +8 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Drug therapy of primary biliary diseases: classical and modern strategies

, 2013
Definition: Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are both cholestatic liver diseases. A common feature of these disorders is the accumulation of bile acids in the liver and blood, presumably because of decreased ...
Leuschner, Ulrich, Schlichting, Julia
core   +1 more source

Clinical Practice Guideline for Primary Liver Cancer(2024 Edition)

Xiehe Yixue Zazhi
Primary liver cancer is one of the common malignant tumors in China. According to the cancer statistics report in China for the year 2022, the incidence and mortality rates of primary liver cancer in our country rank 5th and 2nd, with 367 700 new cases ...
Department of Medical Administration, National Health Commission of the People's Republic of China
doaj   +1 more source

Tumor-suppressive role of Smad ubiquitination regulatory factor 2 in patients with colorectal cancer

Scientific Reports, 2022
Smad ubiquitination regulatory factor 2 (Smurf2) plays various roles in cancer progression. However, the correlation between Smurf2 and clinical outcomes has not been determined in patients diagnosed with colorectal cancer and colorectal liver metastases.
Nami Sato, Nozomu Sakai, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Gaku Ohira, Hideaki Miyauchi, Hisahiro Matsubara, Masayuki Ohtsuka   +9 more
doaj   +1 more source

Impact of sarcopenia and sarcopenic obesity on survival in patients with primary liver cancer: a systematic review and meta-analysis

Frontiers in Nutrition, 2023
BackgroundSarcopenia and sarcopenic obesity are associated with an increased possibility of adverse clinical outcomes; however, the effects of sarcopenia and sarcopenic obesity on patients with primary liver cancer remain controversial.
Xuanmei Li, Xue Huang, Lifu Lei, Shiwen Tong   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source