Results 81 to 90 of about 890,728 (306)

Immune mediated and direct killing of colorectal cancer by reovirus [PDF]

, 2012
Colorectal cancer remains the second most prevalent cancer in the world. Novel treatment strategies are necessary, especially for the treatment of metastatic disease.
Adair, Robert Allan
core  

Liver Cancer

, 2021
Liver tumors are a heterogeneous and complex mix of benign and malignant neoplasms that may arise in the setting of chronic liver injury or due to no prior insult.

core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Unraveling the Regulatory Mechanisms Underlying Tissue-Dependent Genetic Variation of Gene Expression [PDF]

, 2012
It is known that genetic variants can affect gene expression, but it is not yet completely clear through what mechanisms genetic variation mediate this expression.
Harry J M Groen, Veldink, Jan,, Meerman, Gerard J. te,, Groen, Harry JM, Westra, Harm-Jan,, Ophoff, Roel A.,, Wolfs, Marcel G.M.,, Snieder, Harold; id_orcid, Fehrmann, Rudolf S.N.,, Fu, J, Harry J. M. Groen (101726), Groen, H.J., Fu, Jingyuan, Westra, Harm Jan, Wolfs Marcel G. M., Patrick Deelen, Westra, Harm Jan; id_orcid, Wim A Buurman, van Heel David, Weersma, RK, Groen, Harry J.M.,, Marcel G M Wolfs, Marten H. Hofker (102396), Buurman Wim A., Patrick Deelen (187548), Jansen, R.C., Fehrmann, R.S., Weersma, Rinse K; id_orcid, Harm-Jan Westra, Jansen, Ritsert C, Wijmenga, Cisca, Meerman, GJT, Cisca Wijmenga, Gerard J Te Meerman, Franke, L, Fehrmann, RSN, Rensen, SSM, Wolfs, MGM, Jingyuan Fu (102399), Weersma, Rinse K.,, Rinse K. Weersma (131692), van den Berg, Leonard H, Harold Snieder (103613), Rensen, Sander S.M.,, Fu, Jingyuan,, Fehrmann, Rudolf S N, Rensen, Sander S M, van den Berg, L.H., Sander S. M. Rensen (187559), van den Berg Leonard H., Snieder Harold, Heel, David van,, Snieder, Harold,, Leonard H van den Berg, te Meerman, G.J., te Meerman Gerard J., Ritsert C Jansen, Wolfs, M.G., Deelen, Patrick, Snieder, H., Fu Jingyuan, Deelen, P., Cisca Wijmenga (32954), Weersma, R.K., Wijmenga, Cisca,, Roel A. Ophoff (155472), Wim A. Buurman (162734), Fu, Jingyuan; id_orcid, Franke, L., Groen, Hendricus, Ophoff, RA, Wolfs, Marcel GM, Wolfs, Marcel G M, Hofker Marten H., Buurman, WA, Leonard H. van den Berg (119440), van Heel, D., Westra, H-J, Hofker, MH, Lude Franke (102406), Buurman, W.A., Jan Veldink, Groen Harry J. M., Wijmenga, C., Wijmenga Cisca, Veldink, Jan, Meerman, Gerard J te, Lude Franke, Weersma, Rinse K, Jansen, Ritsert C.,, Sander S M Rensen, Wijmenga, C, Harm-Jan Westra (102374), Westra, H.J., Veldink, J., van den Berg, LH, Snieder, Harold, David van Heel (187571), Harold Snieder, David van Heel, Westra, Harm-Jan, Rudolf S. N. Fehrmann (87558), Westra Harm-Jan, Ophoff, Roel A, Deelen Patrick, Berg, Leonard H. van den,, Rensen Sander S. M., Fehrmann, Rudolf SN, Wijmenga, Cisca; id_orcid, Roel A Ophoff, Franke, Lude, Buurman, Wim A.,, Rensen, S.S.M.; id_orcid, Groen, HJM, Ritsert C. Jansen (32125), Deelen, Patrick,, van Heel, David, Rensen, Sander SM, Franke, Lude,, Rensen, S.S.M., Weersma Rinse K., Hofker, Marten H.,, Fehrmann Rudolf S. N., Franke Lude, Jan Veldink (187567), Hofker, M.H., van Heel, D, Snieder, H, Rudolf S N Fehrmann, Buurman, Wim A, Hofker, Marten H, Deelen, P, Marten H Hofker, Veldink Jan, Jingyuan Fu, Veldink, J, Rinse K Weersma, Marcel G. M. Wolfs (187544), Jansen Ritsert C., Ophoff, R.A., Jansen, RC, Gerard J. te Meerman (87570), te Meerman, Gerhardus, Ophoff Roel A., Groen, Hendricus; id_orcid, Fu, J.   +145 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Physicians Infrequently Adhere to Hepatitis Vaccination Guidelines for Chronic Liver Disease [PDF]

, 2013
Background and Goals:Hepatitis A (HAV) and hepatitis B (HBV) vaccination in patients with chronic liver disease is an accepted standard of care. We determined HAV and HBV vaccination rates in a tertiary care referral hepatology clinic and the impact of ...
Dhiraj Yadav, Behari, J, Yadav, D, Sweeney Kaitlyn, Thudi Kavitha, Yadav Dhiraj, Kavitha Thudi, Jaideep Behari, Sweeney, Kaitlyn, Thudi, K, Behari, Jaideep, Thudi, Kavitha, Behari Jaideep, Yadav, Dhiraj, Kaitlyn Sweeney, Sweeney, K   +15 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Trends of primary liver cancer incidence and mortality in the United States: A population-based study over the last four decades.

PLoS ONE
BackgroundPrimary liver cancer is the third leading cause of cancer deaths worldwide and has one of the worst 5-year survival rates. This study examines US primary liver cancer incidence and incidence-based mortality trends over four decades.Research ...
Saryia Adra, Yousef Alabrach, Anas Hashem, Amir Mahmoud, Amani Khalouf, Ahmed El-Khapery, Ali Abdelhay, Mohamad Mansour, Batool Aldaher, Hiba Barqawi, Eman Abu-Gharbieh   +10 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source