Results 81 to 90 of about 4,984,276 (289)

On‐Scanner Correction of Gradient Nonlinearity Bias for Accurate Assessment of Diffusion Heterogeneity Across Bone Sites in Myelofibrosis Patients

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To improve accuracy of apparent diffusion coefficient (ADC) measurement across different bone‐marrow (BM) sites for myelofibrosis (MF) patients. Methods Vendor‐provided ADC gradient nonlinearity correction (GNC) was implemented for 41 MF study subjects on a 3T clinical scanner.
Dariya Malyarenko, Brian D. Ross, Johannes M. Peeters, Ajit Devaraj, Ramin Jafari, Humera Tariq, Kristen M. Pettit, Moshe Talpaz, Gary D. Luker, Thomas L. Chenevert   +9 more
wiley   +1 more source

Methylation of TET2, CBL and CEBPA in Ph-negative myeloproliferative neoplasms [PDF]

, 2010
A loss-of-function mutation of TET2, CBL and CEBPA has been implicated in the pathogenesis or leukaemic transformation of myeloproliferative neoplasm.
Chim, CS, Fung, TK, Wan, TS, Wong, KF
core   +1 more source

Integration of multiparameter flow cytometry score improves prognostic stratification provided by standard models in primary myelofibrosis [PDF]

, 2022
Francesco Mannelli, Sara Bencini, Giacomo Coltro, Giuseppe Gaetano Loscocco, Benedetta Peruzzi, Giada Rotunno, Chiara Maccari, Francesca Gesullo, Miriam Borella, Chiara Paoli, Roberto Caporale, Carmela Mannarelli, Francesco Annunziato, Paola Guglielmelli, Alessandro M. Vannucchi   +14 more
openalex   +1 more source

Leptin receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis

Nature Cell Biology, 2017
Bone marrow fibrosis is a critical component of primary myelofibrosis (PMF). However, the origin of the myofibroblasts that drive fibrosis is unknown.
M. Decker, Leticia Martínez-Morentin, Guannan Wang, Yeojin Lee, Qingxue Liu, Juliana Leslie, Lei Ding   +6 more
semanticscholar   +1 more source

Thermo‐Chemically Modified Silk Scaffolds Reveal Niche‐Driven Regulation of Hematopoiesis and Fibrosis

Small, EarlyView.
We introduce a versatile 3D platform that recreates key physical and biological features of the human bone marrow. By integrating tunable silk biomaterials, stromal cells, and human hematopoietic progenitors, the model captures both healthy and diseased microenvironments, analysis of blood formation, and its disruption in pathological conditions ...
Christian A. Di Buduo, Carolina P. Miguel, Giulia Della Rosa, Vittorio Abbonante, Santo Diprima, Delfina Tosi, Marta Filibian, Daniele Cattaneo, Jugal Kishore Sahoo, Nicola Tirelli, Alessandra Iurlo, Umberto Gianelli, David L. Kaplan, Alessandra Balduini   +13 more
wiley   +1 more source

Recurrent Variceal Bleeding Due to Non-Cirrhotic Portal Hypertension in a Patient with Primary Myelofibrosis: Case Report

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Acute upper gastrointestinal bleeding may arise from variceal or non-variceal sources. Primary myelofibrosis, classified as a subtype of myeloproliferative neoplasms, represents an uncommon clinically significant etiology of non-cirrhotic portal ...
Debora Sitorus, Bariani Anwar, Anastasia Asylia Dinakrisma   +2 more
doaj   +1 more source

CD133 marks a stem cell population that drives human primary myelofibrosis

Haematologica, 2015
Primary myelofibrosis is a myeloproliferative neoplasm characterized by bone marrow fibrosis, megakaryocyte atypia, extramedullary hematopoiesis, and transformation to acute myeloid leukemia.
Ioanna Triviai, Thomas Stübig, Birte Niebuhr, Kais Hussein, Asterios Tsiftsoglou, Boris Fehse, Carol Stocking, Nicolaus Kröger   +7 more
doaj   +1 more source

miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis [PDF]

, 2014
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by megakaryocyte (MK) hyperplasia, bone marrow fibrosis, and abnormal stem cell trafficking. PMF may be associated with somatic mutations in JAK2, MPL, or CALR.
Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative, Investigators, Barosi, Giovanni, Bianchi, Elisa, Bisognin, Andrea, Bogani, Costanza, Bortoluzzi, Stefania, Cazzola, Mario, Fanelli, Tiziana, Ferrari, Sergio, Guglielmelli, Paola, Manfredini, Rossella, Mannarelli, Carmela, Norfo, Ruggiero, Pennucci, Valentina, Pietra, Daniela, Prudente, Zelia, Rambaldi, Alessandro, Rontauroli, Sebastiano, Rosti, Vittorio, Ruberti, Samantha, Sacchi, Giorgia, Salati, Simona, Salmoiraghi, Silvia, Tagliafico, Enrico, Vannucchi, Alessandro M, Zini, Roberta   +25 more
core   +1 more source

Systematization of analytical studies of polycythemia vera, essential thrombocythemia and primary myelofibrosis, and a meta-analysis of the frequency of JAK2, CALR and MPL mutations: 2000–2018

BMC Cancer, 2019
Research into Philadelphia-negative chronic myeloproliferative neoplasms is heterogeneous. In addition, no systematization of studies of polycythemia vera (PV), essential thrombocythemia (ET) or primary myelofibrosis (PMF) have been carried out.
Mónica Mejía-Ochoa, Paola Andrea Acevedo Toro, JA Cardona-Arias   +2 more
semanticscholar   +1 more source

When, which and how to switch: Navigating JAK inhibitors in myelofibrosis

British Journal of Haematology, EarlyView.
Navigating choice of JAK inhibitor (JAKi) therapy for patients with myelofibrosis who are JAKi‐naïve and for those who have previously been treated with a JAKi.
Jennifer O'Sullivan, Imran Omerdeen, Bethan Psaila   +2 more
wiley   +1 more source