Results 11 to 20 of about 178,746 (299)

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry. [PDF]

Journal of the American Medical Association (JAMA), 2019
Importance:Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations of African ancestry compared with European or Asian ancestry.
Abdullahi, Sadiq M, Abu-Amero, Khaled K, Akafo, Stephen, Alhassan, Mahmoud B, Allingham, R Rand, Anderson, Michael G, Ashaye, Adeyinka, Ashley Koch, Allison E, Asimadu, Ifeoma, Aung, Tin, Ayyagari, Radha, Bakayoko, Saydou, Bonnemaijer, Pieter WM, Bowden, Donald W, Bromley, William C, Budenz, Donald L, Carmichael, Trevor R, Challa, Pratap, Chen, Yii-Der Ida, Chuka-Okosa, Chimdi M, Cooke Bailey, Jessica N, Costa, Vital Paulino, Cruz, Dianne A, de Vasconcellos, José Paulo Cabral, DuBiner, Harvey, Ervin, John F, Feldman, Robert M, Fingert, John H, Flamme-Wiese, Miles, Gaasterland, Douglas E, Garnai, Sarah J, Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Girkin, Christopher A, Guirou, Nouhoum, Guo, Xiuqing, Haines, Jonathan L, Hammond, Christopher J, Hauser, Michael A, Herndon, Leon, Hoffmann, Thomas J, Hulette, Christine M, Hydara, Abba, Igo, Robert P, Jorgenson, Eric, Kabwe, Joyce, Khor, Chiea Chuen, Kilangalanga, Ngoy Janvier, Kizor-Akaraiwe, Nkiru, Klaver, Caroline CW, Kuchtey, Rachel W, Lamari, Hasnaa, Li, Zheng, Liebmann, Jeffrey M, Liu, Yutao, Loos, Ruth JF, Melo, Monica B, Milea, Dan, Moroi, Sayoko E, Msosa, Joseph M, Mullins, Robert F, Nadkarni, Girish, Napo, Abdoulaye, Ng, Maggie CY, Nunes, Hugo Freire, Nyamsi, Prisca Biangoup, Obeng-Nyarkoh, Ebenezer, Okeke, Anthony, Okeke, Suhanya, Olaniyi, Olusegun, Olawoye, Olusola, Oliveira, Mariana Borges, Pasquale, Louise R, Perez-Grossmann, Rodolfo A, Pericak-Vance, Margaret A, Qin, Xue, Ramsay, Michele, Resnikoff, Serge, Richards, Julia E, Risch, Neil, Rotter, Jerome I, Schimiti, Rui Barroso, Sim, Kar Seng, Sponsel, William E, Svidnicki, Paulo Vinicius, Taylor, Kent D, Thiadens, Alberta AHJ, Uche, Nkechinyere J, Van Der Heide, Carly J, van Duijn, Cornelia M, Wang, Shih-Hsiu J, Weinreb, Robert N, Wiggs, Janey L, Williams, Susan E, Zangwill, Linda M   +93 more
core   +2 more sources

Primary open-angle glaucoma and farmacoeconomics: Review [PDF]

SANAMED, 2016
Primary open-angle glaucoma (POAG) is defined as a chronic and progressive disease. Date suggested that it is the second most common cause of the blindness in the world. Blindness, as global problem, is partially consequences of poor health insurance, low medical education, etc. The only modifiable risk factor for glaucoma is intraocular pressure. Cost
Tatjana Sarenac-Vulovic, Katarina Janicijevic   +1 more
openaire   +6 more sources

GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma. [PDF]

Nat Commun
The etiology of primary open angle glaucoma is constituted by both intraocular pressure-dependent and intraocular pressure-independent mechanisms.
Huang Y, Plotnikov D, Wang H, Shi D, Li C, Zhang X, Zhang X, Tang S, Shang X, Hu Y, Yu H, Zhang H, Guggenheim JA, He M.   +13 more
europepmc   +4 more sources

Role of Fibronectin in Primary Open Angle Glaucoma [PDF]

Cells, 2019
Primary open angle glaucoma (POAG) is the most common form of glaucoma and the 2nd most common cause of irreversible vision loss in the United States. Nearly 67 million people have the disease worldwide including >3 million in the United States. A major risk factor for POAG is an elevation in intraocular pressure (IOP).
Mark S. Filla, Donna M. Peters, Jennifer A. Faralli   +2 more
openaire   +3 more sources

Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review

Scientific Reports, 2021
Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness in the world and is influenced by various sociodemographic factors. This meta-analysis aims to determine the worldwide prevalence of POAG in the adult general population for ...
Nan Zhang, Jiaxing Wang, Ying Li, B. Jiang   +3 more
semanticscholar   +1 more source

PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects

BioFactors, Volume 48, Issue 6, Page 1226-1249, November/December 2022., 2022
Abstract Ocular allergies are becoming more prevalent as more airborne pollutants, irritants and microbes pervade our environment. Inflammatory and allergic mediators released by dendritic and mast cells within the conjunctiva cause allergic conjunctivitis (AC), a prevalent ocular surface disorder that affects >40% of the world's human population on a ...
Najam A. Sharif
wiley   +1 more source

Specifications of the ACMG/AMP variant curation guidelines for myocilin: Recommendations from the clingen glaucoma expert panel

Human Mutation, Volume 43, Issue 12, Page 2170-2186, December 2022., 2022
Abstract The standardization of variant curation criteria is essential for accurate interpretation of genetic results and clinical care of patients. The variant curation guidelines developed by the American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) in 2015 are widely used but are not gene specific.
Kathryn P. Burdon, Patricia Graham, Johanna Hadler, John D. Hulleman, Francesca Pasutto, Erin A. Boese, Jamie E. Craig, John H. Fingert, Alex W. Hewitt, Owen M. Siggs, Kristina Whisenhunt, Terri L. Young, David A. Mackey, Andrew Dubowsky, Emmanuelle Souzeau   +14 more
wiley   +1 more source

Racial and Ethnic Disparities in Primary Open-Angle Glaucoma Clinical Trials

JAMA Network Open, 2021
Key Points Question What is the prevalence of participants from racial/ethnic minority groups compared with White individuals in primary open-angle glaucoma (POAG) clinical trials? Findings In this meta-analysis of 33 428 POAG clinical trial participants,
Karen Allison, Deepkumar Patel, Leah Greene   +2 more
semanticscholar   +1 more source

Crosstalk between MicroRNA and Oxidative Stress in Primary Open-Angle Glaucoma

International Journal of Molecular Sciences, 2021
Reactive oxygen species (ROS) plays a key role in the pathogenesis of primary open-angle glaucoma (POAG), a chronic neurodegenerative disease that damages the trabecular meshwork (TM) cells, inducing apoptosis of the retinal ganglion cells (RGC ...
Saray Tabak, S. Schreiber-Avissar, E. Beit-Yannai   +2 more
semanticscholar   +1 more source

BEST1 novel mutation causes Bestrophinopathies in six families with distinct phenotypic diversity

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
BEST1 novel mutation causes Bestrophinopathies in six families with distinct phenotypic diversity. Abstract Purpose To report novel BEST1 variants in six Chinese families with bestrophinopathies of two different inheritance modes and analyze the intrafamilial phenotypic diversity.
Shangying Yang, Zhen Li, Wanyu Cheng, Meijiao Ma, Rui Qi, Xue Rui, Yinghua Ren, Xunlun Sheng, Weining Rong   +8 more
wiley   +1 more source