Results 21 to 30 of about 31,245 (204)

Biomarkers of primary open-angle glaucoma [PDF]

Expert Review of Ophthalmology, 2010
Primary open-angle glaucoma (POAG) is a primary neuronal disease of the optic nerve without a definable cause, and is often associated with increased intraocular pressure. Worldwide, POAG is the second leading cause of blindness; there are 45 million people today with POAG and bilateral blindness is present in 4.5 million of these.
Paul A, Knepper, John R, Samples, Beatrice Yjt, Yue   +2 more
openaire   +2 more sources

MicroRNAs as biomarkers in glaucoma and potential therapeutic targets

Neural Regeneration Research, 2022
Glaucoma is a neurodegenerative disease in which optic nerve damage and visual field defects occur. It is a leading cause of irreversible blindness. Its pathogenesis is largely unknown although several risk factors have been identified, with an increase ...
Bridget Martinez, Philip V Peplow
doaj   +1 more source

Mitochondrial damage in the trabecular meshwork occurs only in primary open-angle glaucoma and in pseudoexfoliative glaucoma.

PLoS ONE, 2011
BackgroundOpen-angle glaucoma appears to be induced by the malfunction of the trabecular meshwork cells due to injury induced by oxidative damage and mitochondrial impairment.
Alberto Izzotti, Mariagrazia Longobardi, Cristina Cartiglia, Sergio Claudio Saccà   +3 more
doaj   +1 more source

Effect of myricetin on primary open-angle glaucoma [PDF]

Translational Neuroscience, 2018
Abstract Background Primary open angle glaucoma (POAG) is the most common form of glaucoma, with a multifactorial etiology that results in retinal ganglion cell death and loss of vision. In this study, we assessed the effects of myricetin on the trabecular meshwork cells in POAG.
Yang Qing, Li Ying, Luo Lin
openaire   +3 more sources

Molecular genetics of primary open-angle glaucoma

Indian Journal of Ophthalmology, 2023
Glaucoma is a series of linked optic diseases resulting in progressive vision loss and total blindness due to the acquired loss of retinal ganglion cells.
Manoj Yadav, Aarti Bhardwaj, Anshu Yadav, Rima Dada, Mukesh Tanwar   +4 more
doaj   +1 more source

Association between hypertriglyceridemia and open angle glaucoma: A case report

Indian Journal of Ophthalmology, 2019
Hypertriglyseridemia is a metabolic disorder that can cause vascular dysfucntion and be causally associated with glaucoma. Herein we present the case of a 16-year-old boy with hypertriglyseridemia with open-angle glaucoma.
Mayuri Bakulesh Khamar, Arpita P Sthapak, D Vijayevarshcini, Priyanka M Patel   +3 more
doaj   +1 more source

Multifunctional Catechol‐Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries

Advanced Healthcare Materials, EarlyView.
Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang, Yi‐Ke Lin, Wei‐Li Chen, Ta‐Ching Chen, Jiashing Yu   +4 more
wiley   +1 more source

GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma

Nature Communications
The etiology of primary open angle glaucoma is constituted by both intraocular pressure-dependent and intraocular pressure-independent mechanisms.
Yu Huang, Denis Plotnikov, Huan Wang, Danli Shi, Cong Li, Xueli Zhang, Xiayin Zhang, Shulin Tang, Xianwen Shang, Yijun Hu, Honghua Yu, Hongyang Zhang, Jeremy A. Guggenheim, Mingguang He   +13 more
doaj   +1 more source

Hospitalization characteristics of patients with glaucoma in Central and West Serbia [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2019
Introduction/Objective. Glaucoma is a chronic disease that impairs the optic nerve irreversibly and can lead to serious loss of vision and blindness. As the most frequent out of all, primary open-angle glaucoma has a worldwide incidence of 2.4 million ...
Kocić Sanja, Radević Svetlana, Simić-Vukomanović Ivana, Janićijević Katarina, Janićijević-Petrović Mirjana, Mihailović Nataša   +5 more
doaj   +1 more source

Mechanically Compliant, Precision‐Porous Brain Implants Reduce the Foreign Body Reaction and Guide Regeneration

Advanced Healthcare Materials, EarlyView.
This study explores how the brain responds to implants of different properties. Hydrogels with various mechanical properties and pore sizes were implanted in adult rat brains. It is observed that hydrogels with mechanical property closely matched to the brain and 40 µm pore size elicit a pro‐healing response from the brain by modulating the immune ...
Ian Dryg, Le Zhen, Rebecca Darrow, Savannah Lawton, Lars Crawford, Robert Robinson, Steve Perlmutter, James D. Bryers, Buddy D. Ratner   +8 more
wiley   +1 more source