Results 41 to 50 of about 59,640 (292)

Molecular genetics of primary open-angle glaucoma

Indian Journal of Ophthalmology, 2023
Glaucoma is a series of linked optic diseases resulting in progressive vision loss and total blindness due to the acquired loss of retinal ganglion cells.
Manoj Yadav, Aarti Bhardwaj, Anshu Yadav, Rima Dada, Mukesh Tanwar   +4 more
doaj   +1 more source

Single‐Cell RNA Sequencing of Retina Reveals Nna1 Upregulation in Myopic Diabetic Retinopathy as a Protective Factor Against Diabetic Damage

Advanced Science, EarlyView.
This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie, Yingjun Cai, Bolin Chen, Bowen Li, Jing Zou, Huizhuo Xu   +5 more
wiley   +1 more source

GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma

Nature Communications
The etiology of primary open angle glaucoma is constituted by both intraocular pressure-dependent and intraocular pressure-independent mechanisms.
Yu Huang, Denis Plotnikov, Huan Wang, Danli Shi, Cong Li, Xueli Zhang, Xiayin Zhang, Shulin Tang, Xianwen Shang, Yijun Hu, Honghua Yu, Hongyang Zhang, Jeremy A. Guggenheim, Mingguang He   +13 more
doaj   +1 more source

Rates of macular volume changes in different stages and courses of primary open-angle glaucoma

Journal of Ophthalmology
Purpose: To examine macular volume changes as assessed by optical coherence tomography (OCT) and rates of these changes in different stages and courses of primary open-angle glaucoma (POAG).
M. V. Panchenko, O. M. Honchar, H. Yu. Panchenko, I. V. Kitchenko   +3 more
doaj   +1 more source

POLYMORPHISM OF EYE DRAINAGE SYSTEM CHANGES IN GLAUCOMA

Сибирский научный медицинский журнал, 2019
The study aim was to investigate structural peculiarities of sclera in different types of glaucoma, with an accent on changes of the eye drainage system. Materials and methods.
A. K. Lazareva, E. A. Tashlykova, S. V. Aydagulova, O. N. Kuleshova, V. V. Chernykh   +4 more
doaj   +1 more source

Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism

Advanced Science, EarlyView.
Microglial lipid metabolic dysfunction drives neurodegeneration in glaucoma. We found loss of LRP1 causes lipid accumulation and inflammation. We developed alpinetin‐loaded nanoparticles (AlpNPs) that bind LRP1, activate the PPARγ‐LXRα‐ABCA1 pathway to restore lipid homeostasis, promote an anti‐inflammatory phenotype, and protect retinal ganglion cells,
Miao Wei, Yujia Huo, Jingchang Yuan, Xiao Fan, Xiaochen Wang, Sisi Tan, Xi Gao, Ruotong Ouyang, Hong Li   +8 more
wiley   +1 more source

Hospitalization characteristics of patients with glaucoma in Central and West Serbia [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2019
Introduction/Objective. Glaucoma is a chronic disease that impairs the optic nerve irreversibly and can lead to serious loss of vision and blindness. As the most frequent out of all, primary open-angle glaucoma has a worldwide incidence of 2.4 million ...
Kocić Sanja, Radević Svetlana, Simić-Vukomanović Ivana, Janićijević Katarina, Janićijević-Petrović Mirjana, Mihailović Nataša   +5 more
doaj   +1 more source

Pseudoexfoliative Syndrome and Pseudoexfoliative Glaucoma in Primorsko-Goranska County [PDF]

, 2010
The aim of this study is to evaluate pseudoexfoliative glaucoma (PEX) in Primorsko-Goranska County, Croatia, and its characteristics comparing to primary open angle glaucoma (POAG).
Damir Kovačević, Maja Novak-Stroligo, Tea Čaljkušić-Mance, Zvjezdana Alpeza-Dunato   +3 more
core   +1 more source

A cohort study of duplex Doppler examinations of the carotid artery in primary open angle glaucoma [PDF]

, 2014
Objectives To explore the possibility of pathological change in the common carotid artery at the bifurcation and in the internal carotid artery beyond the bifurcation which could contribute to a reduced diastolic pressure as observed in primary open ...
Aldoori, M. I., Marmion, V. J., Stephenson, John, Woodcock, J. P.   +3 more
core   +1 more source

Mechanochromic Organic Materials: Molecular Mechanisms and Multidimensional Applications

Advanced Physics Research, EarlyView.
Mechanochromic (MC) organic materials change color in response to mechanical force. This review elucidates the molecular mechanisms (e.g., aggregation‐induced emission, AIE) and explores their multidimensional applications in sensors, anti‐counterfeiting, biomedical devices, and structural health monitoring, providing a roadmap for future smart ...
Xiaozhe Yin, Guoliang Niu, Yu Wang, Angela Wittmann, Huiyang Gou, Lang Jiang   +5 more
wiley   +1 more source