Results 91 to 100 of about 114,971 (282)

Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies. [PDF]

, 2018
© The Author(s) 2018. Published by Oxford University Press. All rights reserved. SOX8 is an HMG-box transcription factor closely related to SRY and SOX9.
Ahmed, Aleksandar Rajkovic, Andrew J Duncan, Anu Bashamboo, Barrionuevo, Bashamboo, Bashamboo, Bashamboo, Ben Khelifa, Bhagavath, Caburet, Capucine Hyon, Caroline de Malleray Pichard, Caroline Eozenou, Caroline Schluth-Bolard, Celia Ravel, Chaboissier, Christine Louis-Sylvestre, Cooper, Eduardo H Charreau, Erickson, Etienne Patin, Ewa Rajpert-De Meyts, Gonen, Guth, Harteveld, Hassan Rouba, Huang, Hughes, Inas Mazen, Jakubiczka, Jamsai, Jean-Pierre Siffroi, Joelle Bignon-Topalovic, John C Achermann, Ken McElreavey, Kristian Almstrup, Lavery, Lee, Leila Fusee, Liliana Dain, Lin, Liu, Lourenço, Luca Persani, Marie-Charlotte Dumargne, Marie-France Portnoi, Matzuk, Miguel Reyes-Mugica, Neirijnck, Nelson, Ng, Nicol, O'Bryan, Origa, Pierre Validire, Péterfy, Raffaella Rossetti, Raja Brauner, Ralf Jauch, Ray, Salmon, Sandra Chantot-Bastaraud, Sandra Rojo, Schepers, Sekido, Selma F Witchel, Skakkebaek, Smyk, Sophie Christin-Maitre, Stolt, Stuart MacGowan, Suntharalingham, Sutton, Svetlana A Yatsenko, Violeta A Chiauzzi, W H Irwin McLean, Wang, Yatsenko, Yogesh Srivastava   +79 more
core   +9 more sources

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Cardiovascular RiskprofilE - IMaging and gender-specific disOrders (CREw-IMAGO): Rationale and design of a multicenter cohort study [PDF]

, 2017
Background: Reproductive disorders, such as polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI) and hypertensive pregnancy disorders (HPD) like pre-eclampsia (PE), are associated with an increased risk of cardiovascular disease (CVD ...
Benschop, L. (Laura), Boersma, H. (Eric), Budde, R.P.J. (Ricardo), Fauser, B.C.J.M. (Bart), Franx, A. (Arie), Groot, C.J.M. (Christianne) de, Laven, J.S.E. (Joop), Lugt, A. (Aad) van der, Maas, A.H.E.M. (Angela H.E.M.), Meun, C. (Cindy), Moons, K.G.M. (Karel), Rijn, B.B. (Bas) van, Roeters van Lennep, J.E. (Jeanine), Roos-Hesselink, J.W. (Jolien), Steegers, E.A.P. (Eric), Velthuis, B.K. (Birgitta), Zoet, G.A. (Gerbrand A.)   +16 more
core   +1 more source

Cardiovascular Disease and Primary Ovarian Insufficiency [PDF]

Seminars in Reproductive Medicine, 2011
Cardiovascular disease (CVD) is the number-one killer of women. Women with primary ovarian insufficiency (POI) may be more burdened by cardiovascular disease, such as myocardial infarction and stroke, as compared with women with normal menopause.
openaire   +2 more sources

Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency

Aging, 2020
We aimed to determine whether intraovarian injection of autologous platelet rich plasma (PRP) improves response to ovarian stimulation and in vitro fertilization (IVF) outcome in women with primary ovarian insufficiency (POI).
Y. Çakıroğlu, A. Saltik, Aysen Yuceturk, Ozge Karaosmanoglu, Sule Yildirim Kopuk, R. Scott, B. Tiras, E. Seli   +7 more
semanticscholar   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human disease. [PDF]

, 2015
DAX-1 (NR0B1) and SF-1 (NR5A1) are two nuclear receptor transcription factors that play a key role in human adrenal and reproductive development. Loss of DAX-1 function is classically associated with X-linked adrenal hypoplasia congenita.
Achermann, JC, Buonocore, F, Duncan, AJ, Suntharalingham, JP   +3 more
core   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source