Results 91 to 100 of about 4,572,451 (270)

Endocrinology of Primary Ovarian Insufficiency: Diagnostic and Therapeutic Clues

Endocrines
Background: This paper briefly reviews the most important endocrine features of primary ovarian insufficiency (POI) and shows their relevance for the diagnosis and treatment of this condition.
Jan Tesarik
doaj   +1 more source

Population-based estimates of the prevalence of FMR1 expansion mutations in women with early menopause and primary ovarian insufficiency. [PDF]

, 2014
addresses: University of Exeter Medical School, University of Exeter St Luke's, Exeter, UK.This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.Purpose:Primary ovarian ...
Ennis, S, Schoemaker, MJ, Jones, M, Morris, DH, Swerdlow, AJ, Morris, Danielle H, Macpherson, JN, Murray, Anna, Swerdlow, Anthony J., Anna Murray, Jacobs, PA, Murray, A, Sarah Ennis, Macpherson, James N, Claire E. Bennett, Bennett, Claire E., Minouk J. Schoemaker, Ashworth, Alan, Jacobs, Patricia A, Orr, Nick; id_orcid, Nick Orr, Danielle H. Morris, Orr, Nick, Orr, N, Bennett, Claire E, Ashworth, A, Swerdlow, Anthony J, Morris, Danielle H., Anthony J. Swerdlow, Patricia A. Jacobs, Michael Jones, Alan Ashworth, James N. Macpherson, Jones, Michael, Bennett, CE, Ennis, Sarah, Jacobs, Patricia A., Macpherson, James N., Schoemaker, Minouk J., Schoemaker, Minouk J   +39 more
core   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Cardiovascular Disease and Primary Ovarian Insufficiency [PDF]

Seminars in Reproductive Medicine, 2011
Cardiovascular disease (CVD) is the number-one killer of women. Women with primary ovarian insufficiency (POI) may be more burdened by cardiovascular disease, such as myocardial infarction and stroke, as compared with women with normal menopause.
openaire   +2 more sources

Prospective study of symptoms of ovarian cancer in postmenopausal women [PDF]

, 2010
Background: Research has identified key symptoms of ovarian cancer, although there are gaps in the knowledge about the pattern of symptom onset, severity and frequency. Previous studies are limited by use of non-validated questionnaires, recall bias and
Allen, P.L.
core  

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Roles of Meiotic Defects in Pathogenesis of Primary Ovarian Insufficiency

Reproductive and Developmental Medicine, 2017
A matured oocyte has experienced three critical division stages: (1) proliferation in early fetal stage, (2) meiotic arrest at diplotene of prophase I, and (3) meiotic resumption and extrusion of the first polar body.
Ling Zhang, Qi-Qi Wang, Cheng-Qiu Tao, Cong-Jian Xu   +3 more
doaj   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source