Results 81 to 90 of about 4,572,451 (270)

A rigid hymen in a patient with primary infertility: A case report

Ibom Medical Journal
Infertility is a cause for global concern and is associated with several negative impacts on the couple, especially the female partner. This case report describes a 40 year old lady who presented with inability to conceive for 7 years, severe pains ...
Eyong EM, Eyong ME, Upua CA
doaj   +1 more source

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Association of age at menopause and suicide risk in postmenopausal women: a nationwide cohort study

Frontiers in Psychiatry
IntroductionEarly age at menopause has been linked to various adverse health outcomes, but its association with suicide risk remains underexplored. This study aims to assess the relationship between age at menopause and suicide risk among postmenopausal ...
Daa Un Moon, Daa Un Moon, Daa Un Moon, Hyewon Kim, Jin-Hyung Jung, Kyungdo Han, Hong Jin Jeon, Hong Jin Jeon   +7 more
doaj   +1 more source

Evaluating the role of serum AMH in predicting suboptimal or excessive ovarian response to standard dosing regimen of ovarian stimulation in in-vitro fertilisation using GNRH agonist long protocol [PDF]

, 2011
Introduction: Antral follicle count (AFC) is widely used for individualising gonadotrophin dosage in in-vitro fertilisation (IVF) treatment. This retrospective study tried to determine whether baseline serum anti-Mullerian hormone (AMH) measurement ...
Li, RHW, Ho, PC, Lee, VCY, Lau, EYL, Ng, EHY, Yeung, WSB   +5 more
core  

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source

The Effect of Caffeic Acid on the Morphometrical Changes of Ovarian Follicles in Premature Ovarian Insufficiency Model of Mice [PDF]

Journal of Ardabil University of Medical Sciences
Background: Premature ovarian insufficiency (POI) is the cessation of ovarian function in women under 40. One of the mechanisms involved in the induction of POI is oxidative stress.
Reza Javanshir, Hossein Kalarestaghy, Ramin Salimnejad   +2 more
doaj  

Evaluation of serum heavy metal levels on primary ovarian insufficiency

Medicine Science, 2018
In this study we aimed to investigate the level of exposure to these toxic heavy metals such as Aluminum (Al), Arsenic (As), Mercury (Hg) ,Manganese (Mn) and Lead (Pb) among Premature Ovarian Insufficiency (POI) patients.
Sule Ozel, Ayla Aktulay, Osman Aykut, Hikmet Gulsen Uncu, Hatice Kansu Celik, Sunullah Soysal, Mehmet Cinar, Yaprak Engin Ustun   +7 more
doaj   +1 more source

Primary Ovarian Failure

, 2015
WOS: 000216753300002Primary ovarian failure (POF) is a common cause of infertility in women. It is characterized by amenorrhea, hypoestrogenism and elevated gonadotropin levels in women younger than 40 years of age.
Gülhan Akbaba, Akbaba, Eren, Akbaba, Gulhan, Eren Akbaba   +3 more
core   +1 more source

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source