Results 141 to 150 of about 97,838 (263)

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Metabolome analysis identified exogenous cholesterol within lipid rafts that activate the Akt/mTOR signaling pathway in epithelial ovarian cancer

International Journal of Cancer, EarlyView.
What's New? Epithelial ovarian cancer (EOC) is a severe malignancy with few effective treatment options. While the mechanisms remain unclear, changes in lipid metabolism may fuel tumor growth and EOC progression, offering a possible path for new treatments.
Hitomi Sakaguchi‐Mukaida, Kosuke Hiramatsu, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Tadashi Iwamiya, Shinya Matsuzaki, Tetsuji Naka, Yutaka Ueda, Tadashi Kimura, Michiko Kodama   +10 more
wiley   +1 more source

Tumor‐educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation

International Journal of Cancer, EarlyView.
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon, Min‐Kyung Lee, Eunyong Ahn, Heeyeon Kim, Yong Sang Song, Taejin Ahn   +5 more
wiley   +1 more source

Dynamics of the association between circulating levels of miRNA and pancreatic cancer risk through the years prior to pancreatic cancer diagnosis

International Journal of Cancer, EarlyView.
What's New? Early diagnosis is critical for improving pancreatic ductal adenocarcinoma prognosis, but few biomarkers currently exist. In a case–control study of 1,307 pancreatic cancer cases and matched pairs nested in prospective cohort studies, 13 miRNA–cancer associations were found to change during the blood‐draw‐to‐diagnosis time window.
Hui Cai, Veronica Wendy Setiawan, Xingyi Guo, Jie Wu, Rachael Stolzenberg‐Solomon, Yu‐Tang Gao, Jordan Berlin, Fei Ye, Qiuyin Cai, Wei Zheng, Xiao‐Ou Shu   +10 more
wiley   +1 more source

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

A first‐trimester mechanistic framework integrating three Physiopathologic biomarker domains for pre‐eclampsia classification

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To develop and internally validate a mechanistic, three‐domain framework for early classification and prediction of pre‐eclampsia (PE) using first‐trimester angiogenic, uteroplacental, and maternal vascular biomarkers. Methods In a prospective cohort of 1925 singleton pregnancies screened at 11 to 13.6 weeks, placental growth factor (
Johnatan Torres‐Torres, Salvador Espino‐y‐Sosa, Raigam Jafet Martinez‐Portilla, Elsa Romelia Moreno‐Verduzco, Irma Eloisa Monroy‐Muñoz, Juan Mario Solis‐Paredes, Javier Perez Duran, Hector Borboa‐Olivares, Lourdes Rojas‐Zepeda   +8 more
wiley   +1 more source

Metroplasty before IVF in women with a T‐shaped uterus: A clinical challenge

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract A T‐shaped uterus is a uterine malformation, which can be either congenital or acquired, potentially impairing fertility and increasing the risk of miscarriage. Diagnosis primarily relies on three‐dimensional ultrasound and hysteroscopy. Hysteroscopic metroplasty is the standard surgical intervention aimed at restoring normal uterine anatomy ...
Fabio Barra, Irene Gazzo, Alessandro Favilli, Consuelo Russo, Giulia Monaco, Franco Alessandri, Sandro Gerli, Luis Alonso Pacheco, Caterina Exacoustos, Simone Ferrero   +9 more
wiley   +1 more source

From Genes to Lives: Integrating the Complexities of Primary Ovarian Insufficiency. [PDF]

Int J Mol Sci
Abujaber R, Henry-Smith C, Sharma S.
europepmc   +1 more source

Causal effects of reproductive traits on cognitive function: A two‐sample and multivariable mendelian randomization study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Potential associations between reproductive traits and cognitive function have been discovered; however, the results are inconsistent, and the causalities are unclear. This study utilized Mendelian randomization (MR) analysis to assess the causal impact of reproductive traits on cognitive function.
Xia Wang, Yunyun Guo
wiley   +1 more source

Nanomotor-Driven Extracellular Vesicles With Effective Tissue Penetration for Targeted Therapy of Primary Ovarian Insufficiency. [PDF]

J Extracell Vesicles
Mu Y, Wu J, Lv M, Zhang X, Song Y, Ai J, Ma D, Li K.   +7 more
europepmc   +1 more source