Results 211 to 220 of about 97,838 (263)

Does preimplantation genetic testing for aneuploidy improve live birth rate in women diagnosed with recurrent implantation failure: A systematic review and meta‐analysis?

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Preimplantation genetic testing for aneuploidy may improve both live birth rate per embryo transfer and cumulative live birth rate per cycle for women diagnosed with recurrent implantation failure. Abstract Introduction The prevalence of unexplained recurrent implantation failure (RIF) is reported as 2%–15% in the literature.
Amy Newnham, Charlotte Leeson, Fatima Trunkwala, Joshua Odendaal, Siobhan Quenby   +4 more
wiley   +1 more source

Heterozygous Eif4nif1 Stop-Gain Mice Replicate the Primary Ovarian Insufficiency Phenotype in Women.

Endocrinology
Moriwaki M, Liu L, James ER, Tolley ND, O'Connor AM, Emery B, Aston KI, Campbell RA, Welt CK.   +8 more
europepmc   +1 more source

Port‐site hernia following laparoscopic gynecological surgery: A systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
This systematic review of 70 346 patients revealed an estimated incidence of port‐site hernia of 0.29%. Fascial closure reduces risk but does not eliminate port‐site hernia, and no specific closure technique shows clear superiority. Abstract Introduction Port‐site hernia (PSH) is a rare but clinically relevant complication of laparoscopic gynecologic ...
Franciszek Ługowski, Zofia Włodarczyk, Anna Owczarek, Łucja Zaborowska, Artur Ludwin   +4 more
wiley   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, EarlyView.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

Clinical Applications of Phosphoproteomics: Illuminating Cancer Signaling and Enabling Rational Therapeutic Strategies

Cancer Science, EarlyView.
Mass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Hirokazu Shoji, Narikazu Boku, Jun Adachi   +2 more
wiley   +1 more source

Refining Tumor Mutational Burden as a Predictive Biomarker for Pembrolizumab: A Real‐World Analysis in Japanese Patients

Cancer Science, EarlyView.
In this study, we investigated the predictive value of tumor mutational burden (TMB) for assessing the efficacy of pembrolizumab in a Japanese cohort. We analyzed real‐world data from 63,952 patients registered in the C‐CAT database who underwent comprehensive genomic profiling, and evaluated the therapeutic efficacy of pembrolizumab in 1899 of these ...
Tomoyo Yasuda, Mio Yumura, Azusa Hamasaki, Tongyi Fei, Takashi Kubo, Hitoshi Ichikawa, Takashi Kohno, Kuniko Sunami   +7 more
wiley   +1 more source

Aberrant downregulation of Y-box binding protein 1 expression impairs the cell cycle in an m⁵C-dependent manner in human granulosa cells from patients with primary ovarian insufficiency. [PDF]

Cell Mol Life Sci
Chen Q, Wang S, Zhang M, Xiang Y, Chen Q, Li Z, Song Y, Bai L, Zhu Y.   +8 more
europepmc   +1 more source