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The Lancet, 2010
Primary ovarian insufficiency is a subclass of ovarian dysfunction in which the cause is within the ovary. In most cases, an unknown mechanism leads to premature exhaustion of the resting pool of primordial follicles. Primary ovarian insufficiency might also result from genetic defects, chemotherapy, radiotherapy, or surgery.
De Vos, Michel +2 more
exaly +8 more sources
Primary ovarian insufficiency is a subclass of ovarian dysfunction in which the cause is within the ovary. In most cases, an unknown mechanism leads to premature exhaustion of the resting pool of primordial follicles. Primary ovarian insufficiency might also result from genetic defects, chemotherapy, radiotherapy, or surgery.
De Vos, Michel +2 more
exaly +8 more sources
Primary Ovarian Insufficiency and Ovarian Aging
Obstetrics and Gynecology Clinics of North America, 2023Primary ovarian insufficiency (POI) is a complex condition of aberrant ovarian aging. POI etiologies are varied, and most cases have no identifiable underlying cause. Caring for women with POI requires an approach that understands the importance of ovarian function in a variety of target organs and tissues.
Lauren Verrilli
openaire +3 more sources
Autoimmune primary ovarian insufficiency
Autoimmunity Reviews, 2014Primary ovarian insufficiency (POI) is defined as sustained amenorrhea, increased follicle-stimulating hormone and low estrogen levels, whereas diminished ovarian reserve (DOR) is characterized as regular menses and alterations of ovarian reserve tests.
C A, Silva +5 more
openaire +2 more sources
Seminars in Reproductive Medicine, 2016
Primary ovarian insufficiency (POI), also known as premature ovarian failure or premature menopause, is defined as cessation of menstruation before the expected age of menopause. Potential etiologies for POI can be divided into genetic, autoimmune, and iatrogenic categories.
openaire +4 more sources
Primary ovarian insufficiency (POI), also known as premature ovarian failure or premature menopause, is defined as cessation of menstruation before the expected age of menopause. Potential etiologies for POI can be divided into genetic, autoimmune, and iatrogenic categories.
openaire +4 more sources
Journal of Reproductive Immunology, 2023
OBJECTIVE Stem cell/exosome therapy is a novel strategy for primary ovarian insufficiency (POI). This paper is to examine the role of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hUCMSC-EVs) in POI. METHODS hUCMSC-EVs were
Yan Lu +7 more
semanticscholar +1 more source
OBJECTIVE Stem cell/exosome therapy is a novel strategy for primary ovarian insufficiency (POI). This paper is to examine the role of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hUCMSC-EVs) in POI. METHODS hUCMSC-EVs were
Yan Lu +7 more
semanticscholar +1 more source
Journal of Clinical Endocrinology and Metabolism, 2023
CONTEXT POI is a heterogeneous disease with an unknown underlying trigger or root cause. Recently many studies evaluated non-coding RNAs (ncRNAs), especially microRNAs (miRNAs), long non-coding RNA (lncRNAs), circular RNAs (circRNAs), and short ...
Jun-Hui Zhang +6 more
semanticscholar +1 more source
CONTEXT POI is a heterogeneous disease with an unknown underlying trigger or root cause. Recently many studies evaluated non-coding RNAs (ncRNAs), especially microRNAs (miRNAs), long non-coding RNA (lncRNAs), circular RNAs (circRNAs), and short ...
Jun-Hui Zhang +6 more
semanticscholar +1 more source
Genetics of Primary Ovarian Insufficiency
Clinical Obstetrics & Gynecology, 2020The diagnosis of primary ovarian insufficiency (POI) has untold effects on women and a better understanding alongside potential treatments are paramount to improve quality of life of these women. Various causes have been linked to the development of POI with genetics playing a key role.
Rukayat O, Akande, Yetunde, Ibrahim
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2017
Premature ovarian insufficiency (POI) can be defined as a cessation of ovarian function in women younger than 40 years old and is linked to the development of hypergonadotropic hypogonadism. The hypogonadism clinically presents as amenorrhea, which sometimes is preceded by oligomenorrhea and decreased circulating estradiol levels.
Agnieszka Podfigurna +4 more
openaire +2 more sources
Premature ovarian insufficiency (POI) can be defined as a cessation of ovarian function in women younger than 40 years old and is linked to the development of hypergonadotropic hypogonadism. The hypogonadism clinically presents as amenorrhea, which sometimes is preceded by oligomenorrhea and decreased circulating estradiol levels.
Agnieszka Podfigurna +4 more
openaire +2 more sources