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Seminars in Reproductive Medicine, 2016 Primary ovarian insufficiency (POI), also known as premature ovarian failure or premature menopause, is defined as cessation of menstruation before the expected age of menopause. Potential etiologies for POI can be divided into genetic, autoimmune, and iatrogenic categories.
Joop Laven
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Primary Ovarian Insufficiency and Ovarian Aging
Obstetrics and Gynecology Clinics of North America, 2023Primary ovarian insufficiency (POI) is a complex condition of aberrant ovarian aging. POI etiologies are varied, and most cases have no identifiable underlying cause. Caring for women with POI requires an approach that understands the importance of ovarian function in a variety of target organs and tissues.
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Primary ovarian insufficiency: autoimmune causes
Current Opinion in Obstetrics & Gynecology, 2010 To review the pathogenesis of premature ovarian insufficiency due to steroid cell autoimmunity (SCA-POI).Autoimmune oophoritis is characterized by a selective mononuclear cell infiltration into the theca layer of large, antral follicles, with earlier stage follicles consistently free of lymphocytic infiltration.
A. La Marca +5 more
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Genetics of Primary Ovarian Insufficiency
Seminars in Reproductive MedicineAbstract Primary ovarian insufficiency (POI) is a heterogeneous condition that worldwide affects up to 3.7% of women under 40 years of age. POI manifestations are diverse, ranging from ovarian dysgenesis and primary amenorrhea to a later onset ovarian dysfunction, secondary amenorrhea, and diminished ovarian reserve.
Svetlana A. Yatsenko +1 more
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FMR1 and the Continuum of Primary Ovarian Insufficiency
Seminars in Reproductive Medicine, 2011Spontaneous 46,XX primary ovarian insufficiency (POI) is a term that describes ovarian dysfunction resulting in a range of abnormalities, from infertility to early menopause as the end stage (overt POI). The most common known genetic cause of 46,XX POI is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked ...
Stephanie Sherman, Corrine Welt
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Fertility in adult women with classic galactosemia and primary ovarian insufficiency [PDF]
Fertility and Sterility, 2017 Item does not contain fulltextOBJECTIVE: To study pregnancy chance in adult women with classic galactosemia and primary ovarian insufficiency. Despite dietary treatment, >90% of women with classic galactosemia develop primary ovarian insufficiency ...
Gérard Berry +2 more
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The Lancet, 2010
Primary ovarian insufficiency is a subclass of ovarian dysfunction in which the cause is within the ovary. In most cases, an unknown mechanism leads to premature exhaustion of the resting pool of primordial follicles. Primary ovarian insufficiency might also result from genetic defects, chemotherapy, radiotherapy, or surgery.
De Vos, Michel +2 more
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Primary ovarian insufficiency is a subclass of ovarian dysfunction in which the cause is within the ovary. In most cases, an unknown mechanism leads to premature exhaustion of the resting pool of primordial follicles. Primary ovarian insufficiency might also result from genetic defects, chemotherapy, radiotherapy, or surgery.
De Vos, Michel +2 more
+7 more sources
Genetics of Primary Ovarian Insufficiency
Clinical Obstetrics & Gynecology, 2020The diagnosis of primary ovarian insufficiency (POI) has untold effects on women and a better understanding alongside potential treatments are paramount to improve quality of life of these women. Various causes have been linked to the development of POI with genetics playing a key role.
Rukayat O, Akande, Yetunde, Ibrahim
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Autoimmune primary ovarian insufficiency
Autoimmunity Reviews, 2014Primary ovarian insufficiency (POI) is defined as sustained amenorrhea, increased follicle-stimulating hormone and low estrogen levels, whereas diminished ovarian reserve (DOR) is characterized as regular menses and alterations of ovarian reserve tests.
C A, Silva +5 more
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