Results 51 to 60 of about 97,838 (263)

Mitochondrial Dysfunction in Primary Ovarian Insufficiency [PDF]

Endocrinology, 2019
Abstract Primary ovarian insufficiency (POI) is defined by the loss or dysfunction of ovarian follicles associated with amenorrhea before the age of 40. Symptoms include hot flashes, sleep disturbances, and depression, as well as reduced fertility and increased long-term risk of cardiovascular disease.
Dov Tiosano, Jason A Mears, David A Buchner   +2 more
openaire   +2 more sources

Primary Ovarian Insufficiency [PDF]

New England Journal of Medicine, 2009
A 30-year-old woman presents with a history of no menses since she stopped taking oral contraceptives 6 months ago in order to conceive. She had undergone puberty that was normal in both timing and development, with menarche at 12 years of age. At 18 years of age, she started taking oral contraceptives for irregular menses.
openaire   +1 more source

Normogonadotropic ovarian insufficiency in adolescence (review of literature and clinical case)

Mìžnarodnij Endokrinologìčnij Žurnal, 2017
The objective of the review. Analysis of literature data related to the normogonadotropic ovarian insufficiency. Basic statements. The article presents a literature review and clinical case of normogonadotropic ovarian insufficiency in girls aged 16 ...
T.V. Sorokman, S.V. Sokolnyk, P.M. Moldovan, N.O. Popeliuk   +3 more
doaj   +1 more source

Facilitation of Ovarian Response by Mechanical Force—Latest Insight on Fertility Improvement in Women with Poor Ovarian Response or Primary Ovarian Insufficiency

International Journal of Molecular Sciences, 2023
The decline in fertility in aging women, especially those with poor ovarian response (POR) or primary ovarian insufficiency (POI), is a major concern for modern IVF centers.
Chia-Lin Chang
semanticscholar   +1 more source

Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells

Autophagy, 2022
Primary ovarian insufficiency (POI), also known as premature ovarian failure, is an ovarian defect in humans characterized by the premature depletion of ovarian follicles before the age of 40. However, the mechanisms underlying POI remain largely unknown.
Wenwen Liu, Min Chen, Chao Liu, Liying Wang, Huafang Wei, Ruidan Zhang, Zhengxing Ren, Yinghong Chen, Mengcheng Luo, Jianguo Zhao, Hongwei Jiang, F. Gao, Wei Li   +12 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Autoimmune premature ovarian failure

Menopause Review, 2017
Premature ovarian failure (POF), also termed as primary ovarian insufficiency (POI), is a highly heterogenous condition affecting 0.5-3.0% of women in childbearing age.
Beata Komorowska
doaj   +1 more source

Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with cyclophosphamide-induced primary ovarian insufficiency

Journal of Biomedical Sciences
Primary ovarian insufficiency (POI) is an early decline in ovarian function that leads to ovarian failure. Conventional treatments for POI are inadequate, and treatments based on mesenchymal stem cells (MSCs) have emerged as an option.
Duy-Cuong Le, M. T. Ngo, Yung-Che Kuo, Shu-Hwa Chen, Chung-Yen Lin, T. Ling, Q. T. T. Pham, Heng-Kien Au, Jihwan Myung, Yen-Hua Huang   +9 more
semanticscholar   +1 more source

Follicle development and its prediction in patients with primary ovarian insufficiency: Possible treatments and markers to maximize the ability to conceive with residual follicles

Reproductive Medicine and Biology, 2023
Primary ovarian insufficiency (POI) is characterized by the development of hypergonadotropic hypogonadism before 40 years of age and leads to intractable infertility. Although in vitro fertilization and embryo transfer with donated eggs enables pregnancy,
S. Osuka, Yukiyo Kasahara, S. Iyoshi, R. Sonehara, Natsuki Myake, A. Muraoka, Tomoko Nakamura, Akira Iwase, Hiroaki Kajiyama   +8 more
semanticscholar   +1 more source

An update on primary ovarian insufficiency [PDF]

Science China Life Sciences, 2012
Primary ovarian insufficiency (POI) occurs in about 1% of female population under the age of 40, leading to reproductive problems, an earlier encounter with menopausal symptoms, and complicated diseases. There are three presumable mechanisms involved in the development of POI, namely apoptosis acceleration, follicular maturation blocking and premature ...
Jin, Min, Yu, YiQi, Huang, HeFeng
openaire   +2 more sources