Results 81 to 90 of about 97,838 (263)

The prevalence of primary ovarian insufficiency in Sweden; a national register study

BMC Women's Health, 2018
Background The current estimates of the prevalence of primary ovarian insufficiency (POI) are very variable, but are in most studies believed to be around 1%. It is also very likely tat the prevalence of POI differs between countries and over time.
Katarina Lagergren, Mats Hammar, Elizabeth Nedstrand, Marie Bladh, Gunilla Sydsjö   +4 more
doaj   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Women with primary ovarian insufficiency have lower bone mineral density

Brazilian Journal of Medical and Biological Research, 2011
The aim of the present study was to assess the prevalence of osteoporosis in a sample of 32 patients with spontaneous primary ovarian insufficiency (POI) in comparison to reference groups of 25 pre- and 55 postmenopausal women.
F. Amarante, L.C. Vilodre, M.A. Maturana, P.M. Spritzer   +3 more
doaj   +3 more sources

The Genetics of Non-Syndromic Primary Ovarian Insufficiency: A Systematic Review [PDF]

International Journal of Fertility and Sterility, 2019
Several causes for primary ovarian insufficiency (POI) have been described, including iatrogenic and environmental factor, viral infections, chronic disease as well as genetic alterations.
Roberta Venturella, Valentino De Vivo, Annunziata Carlea, Pietro D’Alessandro, Gabriele Saccone, Bruno Arduino, Francesco Paolo Improda, Daniela Lico, Erika Rania, Carmela De Marco, Giuseppe Viglietto, Fulvio Zullo   +11 more
doaj   +1 more source

A metabolome-wide Mendelian randomization study prioritizes causal circulating metabolites for reproductive disorders including primary ovarian insufficiency, polycystic ovary syndrome, and abnormal spermatozoa

Journal of Ovarian Research
Accumulating studies have highlighted the significant role of circulating metabolomics in the etiology of reproductive system disorders. However, the causal effects between genetically determined metabolites (GDMs) and reproductive diseases, including ...
Shuang Chen, Shihao Sun, Mingshu Cai, Zhaokai Zhou, Yuan Ma, Zihan Zhou, Fang Wang, Jinhao Liu, Wenyan Song, Yu Liu, Kai Huang, Qingling Yang, Yihong Guo   +12 more
semanticscholar   +1 more source

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

Does the Serum Vaspin Level Have a Role in the Diagnosis of Primary Ovarian Insufficiency?

Gynecology Obstetrics & Reproductive Medicine
OBJECTIVE: This study was designed to compare the serum vaspin levels between patients with primary ovarian insufficiency (POI) and healthy fertile women.
Fatma Nur Koyun, Nafiye Yilmaz, Duygu Tugrul Ersak   +2 more
doaj   +1 more source

The association between primary ovarian insufficiency and increased multimorbidity in a large prospective cohort.

Fertility and Sterility
OBJECTIVE To describe the prevalence of multimorbidity among individuals with premature ovarian insufficiency (POI) and early menopause, in comparison to average age of menopause.
A. Kirubarajan, N. Sohel, Alexandra J Mayhew, Lauren E. Griffith, Parminder Raina, Alison Shea   +5 more
semanticscholar   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source