Results 61 to 70 of about 5,924,380 (291)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Meshing Stiffness Calculation and Main Resonance Analysis of Helical Gear Transmission

工程科学与技术, 2019
Helical gear is an important element of mechanical equipment. The accurate calculation of meshing stiffness and the stability analysis of the transmission system have important practical significance.
Huirong SHI, Dongyan ZHAO, Zonggang LI
doaj  

Primary hepatic neuroendocrine tumor: Gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging

Acta Radiologica Open, 2013 2013
We present a case of a 71-year-old man with prostate cancer who had no prior underlying liver disease. During metastatic evaluation, a solid mass in the liver was identified by computed tomography and ultrasound.
Soo-Heui Baek, Jung-Hee Yoon, Kwan-Woo Kim   +2 more
doaj   +1 more source

Neuromorphometry of primary brain tumors by magnetic resonance imaging [PDF]

Journal of Medical Imaging, 2015
Magnetic resonance imaging is a technique for the diagnosis and classification of brain tumors. Discrete compactness is a morphological feature of two-dimensional and three-dimensional objects. This measure determines the compactness of a discretized object depending on the sum of the areas of the connected voxels and has been used for understanding ...
Nidiyare, Hevia-Montiel, Pedro I, Rodriguez-Perez, Paul J, Lamothe-Molina, Alfonso, Arellano-Reynoso, Ernesto, Bribiesca, Marco A, Alegria-Loyola   +5 more
openaire   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Quasi-resonant converter with divided resonant capacitor on primary and secondary side

INTELEC 2009 - 31st International Telecommunications Energy Conference, 2009
This paper presents a quasi-resonant converter with divided resonant capacitor on primary and secondary side of the isolation transformer. A conventional quasi-resonant converter using flyback topology can realize soft switching with simple circuit. However, relatively large surge voltage is generated in the switching device.
Hironobu Shiroyama, Hirofumi Matsuo, Yoichi Ishizuka   +2 more
openaire   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The radical cation of bacteriochlorophyll b. A liquid-phase endor and triple resonance study [PDF]

, 1986
The previous termradical cationnext term of bacterioehlorophyll b (BChl b) is investigated by ENDOR and TRIPLE resonance in liquid solution. The experimental hyperfine coupling constants, ten proton and three nitrogen couplings, are compared with the ...
Lendzian, F., Tränkle, E., F. Lendzian, Steiner, R., K. Möbius, Möbius, K., M. Plato, W. Lubitz, Scheer, Hugo, E. Tränkle, Plato, M., H. Scheer, Lubitz, Wolfgang, R. Steiner   +13 more
core   +1 more source

Severe Dietary Energy Restriction for Compensated Cirrhosis Due to Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Randomised Controlled Trial

Journal of Cachexia, Sarcopenia and Muscle
Background Compensated cirrhosis due to metabolic dysfunction‐associated steatotic liver disease (CC‐MASLD) increases morbidity and mortality risk but has no aetiology‐specific treatment.
Dimitrios A. Koutoukidis, Susan A. Jebb, Jeremy W. Tomlinson, Ferenc E. Mozes, Michael Pavlides, Miriam Lacharie, Francesca Saffioti, Paul Aveyard, Jeremy F. Cobbold   +8 more
doaj   +1 more source

The response of nonlinear controlled system under an external excitation via time delay state feedback

Journal of King Saud University: Engineering Sciences, 2016
An analysis of primary, superharmonic of order five, and subharmonic of order one-three resonances for non-linear s.d.o.f. system with two distinct time-delays under an external excitation is investigated.
A.M. Elnaggar, K.M. Khalil
doaj   +1 more source