Results 71 to 80 of about 2,015,776 (282)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Analysis of salivary level Lactobacillus spp. and associated factors as determinants of dental caries amongst primary school children in Harar town, eastern Ethiopia

BMC Pediatrics, 2020
Background Lactobacillus spp. play a major role in the development of dental caries. Although effective methods are known for the prevention and management of dental caries, its prevalence of dental caries is increasing amongst school-age children in ...
Dawit Ademe, Desalegn Admassu, Senthilkumar Balakrishnan   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Parenting Self Efficacy in Mothers of Children with Attention Deficit Hyperactivity Disorder vs. Normal Children.

Iranian Journal of Psychiatry, 2012
The main purpose of this study was to compare parenting self efficacy between mothers of children with attention deficit-hyperactivity disorder (ADHD) and mothers of normal children.One hundred twenty mothers including 60 mothers of children with ADHD ...
Zahra Gohari, Fatemeh Dehghani, Gilda Rajabi, Javad Mahmoudi-Gharaei   +3 more
doaj  

Feminization of Teaching: Female Teachers at Primary and Lower Secondary Schools in Baden-Württemberg, Germany: From Its Beginnings to the Present

Knowledge and Space, 2019
The teaching profession was one of the first in which women were allowed to practice and from today’s perspective is understood as a feminized profession. The process of feminization in teaching developed differently at various levels of school education
J. Schmude, Sascha Jackisch
semanticscholar   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The impact of hearing impairment on Aboriginal children’s school attendance in remote Northern Territory: a data linkage study

Australian and New Zealand Journal of Public Health, 2019
Objective: To investigate the association between hearing impairment (HI) and Year 1 school attendance in Aboriginal children in the Northern Territory (NT) of Australia.
Jiunn-Yih Su, Vincent Yaofeng He, Steven Guthridge, Damien Howard, Amanda Leach, Sven Silburn   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Investigation Anxiety Level and its Effect on Learning Performance among Primary School Students: A cross-sectional Survey

Journal of Nature and Science of Medicine
Background and Objectives: Anxiety among primary school children is one of the most popular, which has negative social, psychological, educational, and physical repercussions on children and families.
Noor Tareq Hamadi, Haider Mohammed Majeed   +1 more
doaj   +1 more source

Challenges and accomplishments of ELT at primary level in Chile: Towards the aspiration of becoming a bilingual country

, 2016
This paper explores the policy development supporting the implementation of English language teaching (ELT) in Chile at primary level over the last two decades.
Malba Barahona, J. Ramírez-Romero
semanticscholar   +1 more source