Results 131 to 140 of about 2,288,786 (311)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

School and student characteristics related to primary and secondary school students’ social–emotional functioning

Frontiers in Education
IntroductionA healthy social–emotional functioning is vital for students’ general development and wellbeing. The school environment is a major determinant of social–emotional functioning, yet little is known about school-level and student-level ...
Anne G. M. de Bruijn, Melanie C. M. Ehren, Martijn Meeter, Anne Fleur Kortekaas-Rijlaarsdam   +3 more
doaj   +1 more source

The Impact of Early Schooling on Subsequent Literacy and Numeracy Performance - Estimates from a Policy Induced 'Natural' Experiment [PDF]

This paper exploits a policy-induced natural experiment that occurred in South Australia in the mid-1980s to generate a 'causal' estimate of the effect of schooling on the literacy and numeracy performance of school students in their middle years of ...
Chris Ryan
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

HEALTHY LIFESTYLE: THE ROLE OF EDUCATION IN IMPROVEMENT OF THE KNOWLEDGE OF PRIMARY AND MIDDLE SCHOOL STUDENTS IN ISFAHAN AND NAJAF-ABAD

ARYA Atherosclerosis, 2010
  INTRODUCTION: Lifestyle habits are established from early childhood and persist for many years, almost until the end of life. Thus, healthy lifestyle education should begin in childhood. This study was conducted to train primary and middle school
Mojgan Soghrati, Roya Kelishadi, Rezvan Pashmi, Razieh Omidi   +3 more
doaj  

Selective mechanisms for general science education : a history of the development of general science education in New Zealand, 1900-1943 : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Arts in History at Massey University [PDF]

, 2000
Free education has been the right of every New Zealand citizen since 1877 when free secular education was established in all state primary schools.¹ Ian Cumming and Alan Cumming, History of State Education in New Zealand 1840-1975, Wellington: Pitman ...
Nikoloff, Lynette L
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Analyzing Students’ Discrimination in Primary School

Jurnal Sains Sosial dan Humaniora, 2017
The negative stigma which causes discrimination appears because of someone’s point of view towards the diversity of race, religion, social, or culture. This diversity can also be found in primary school.
Analisa Listanti, Sri Harmianto, Sriyanto Sriyanto   +2 more
doaj  

Examining Roma Primary School Students' Expectations From School

Revista de Gestão Social e Ambiental
Objective: The aim of this study is to reveal what the expectations of Roma primary school students residing in Doğanlar Neighborhood in Konya are from school.   Theoretical Framework: The basis of this research is the expectations of Roma students from school. There are not many studies on Roma students in the literature.  This research is important
openaire   +1 more source

Compensatory education for disadvantaged Mexican students : an impact evaluation using propensity score matching [PDF]

The authors use propensity score matching to evaluate the effectiveness of CONAFE, a compensatory education program in Mexico, in improving student test scores and lowering repetition and failure rates.
Shapiro, Joseph, Trevino, Jorge Moreno
core