Results 41 to 50 of about 101,199 (219)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Implementation of community-driven initiative program in strengthening discipline character in elementary school

Jurnal Ilmiah Pendidikan Dasar
Discipline is a fundamental aspect in shaping students character within the school environment. However, in reality, various forms of student non-compliance with school regulations are still found, such as tardiness, lack of involvement in the daily ...
Putri Sulistia Zulfasari, Hanum Hanifa Sukma   +1 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Mathematics Learning Difficulties among Elementary School Students

Journal for Lesson and Learning Studies
Mathematics learning difficulties remain a significant challenge faced by many elementary school students. This issue directly impacts students' low academic achievement in mathematics.
Fitri Yabashiru, Berta Apriza, Karsoni Berta Dinata   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Ethnosocial-Based Differentiated Digital Learning Model to Enhance Nationalistic Insight

Open Education Studies
The low level of nationality awareness among primary school students, which resulted from inadequate learning, served as the research basis. A learning model was developed to facilitate this, namely the ethnosocial-based differentiated digital learning ...
Asnawi, Kenedi Ary Kiswanto, Sahudra Tengku Muhammad, Ramadhani Dini, Fransyaigu Ronald, Mardin Asna, Arwin   +6 more
doaj   +1 more source

The Effectiveness of Modified Children’s Songs as a Teaching Tool in Indonesian Language Instruction for Expanding the Vocabulary of Elementary School Students

Mimbar Ilmu
Indonesian language learning in elementary schools still faces challenges in students’ mastery of new vocabulary due to the limited use of engaging learning media that suit students’ characteristics.
Febi Hauliya, Maria Goreti Rini Kristiantari, Anak Agung Ayu Dewi Sutyaningsih   +2 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Ethno-Design-Based Learning Tools to Enhance Students' Future Thinking

Journal for Lesson and Learning Studies
The ability to think about the future is one of the important 21st century competencies that needs to be developed in elementary school students to face dynamic global challenges. However, the implementation of learning in elementary schools still tends
Putu Okta Satriani, I Wayan Widiana, I Wayan Ardana   +2 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source