Results 61 to 70 of about 4,427,643 (140)

Methotrexate‐Loaded Liposomal Formulation Enables 6‐Week Sustained Intraocular Therapeutic Drug Release in a Porcine Model

Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
A liposomal formulation for methotrexate enables minimally invasive, sustained intraocular drug delivery for over six weeks with a single injection. Developed for treating intraocular diseases like lymphoma and PVR, it offers excellent biocompatibility in vivo in a porcine model.
Maximilian Hammer, Lea Skrzypczyk, Sabrina Wohlfart, Bryan Calder Ackermann, Ludwig Geisweid, Simon William Pohl, Margarita Karaivanova, Jonathan Herth, Victor Aristide Augustin, Alexander Studier‐Fischer, Tina Sackmann, Leon Kaulen, Anna Steyer, Walter Mier, David H Steel, Kanmin Xue, Gerd Uwe Auffarth, Philipp Uhl   +17 more
wiley   +1 more source

Long‐Term Real‐World Outcomes of Primary CNS Lymphoma Patients Treated With MATRix Regimen Are Similar to IELSG32 Trial Results

Hematological Oncology, Volume 43, Issue 6, November 2025.
ABSTRACT Primary central nervous system lymphomas (PCNSL) are rare malignancies with poor survival outcomes. The IELSG32 trial demonstrated efficacy of MATRix chemoimmunotherapy followed by autologous stem cell transplantation (auto‐SCT) in PCNSL patients aged ≤ 70 years with a performance status (PS) ECOG ≤ 3.
Prokop Vodicka, Andrea Janikova, David Belada, Veronika Hanackova, Heidi Mocikova, Juraj Duras, Katerina Steinerova, Katerina Benesova, Eva Konirova, Tomas Prochazka, Kamila Polgarova, Michal Masar, Jitka Dlouha, Petra Blahovcova, Marek Trneny   +14 more
wiley   +1 more source

Investigating Microinvasive Intra‐Ocular Biopsy

Clinical &Experimental Ophthalmology, Volume 53, Issue 8, Page 996-1007, November 2025.
ABSTRACT Background Current minimally invasive methods of intraocular biopsy are confined to small gauge (G) needles and subretinal cannulae that can be prone to wound leakage at the biopsy site. We investigate the role of microneedles with internal diameters as small as 49G for intraocular biopsy in the posterior and anterior segments.
Jared Ching, Shohei Kitahata, Hinako Ichikawa, Kazuaki Kadonosono   +3 more
wiley   +1 more source

Uveitis Masquerade Syndrome

Ukrainian Journal of Ophthalmology
The ‘uveitis masquerade syndrome’ is a large group of neoplastic and non-neoplastic conditions that mimic and are initially misdiagnosed as uveitis.
M. K. Shields, L. B. Ferreira, A. L. Farrall, J. R. Smith   +3 more
doaj   +1 more source

Specific Marker Gene Analysis for Primary Central Nervous System Lymphoma Based on Methylation Difference and Development of Detection Primers

Brain and Behavior, Volume 15, Issue 10, October 2025.
Promoter hypermethylation of the RHEB gene is identified as a specific biomarker for Primary Central Nervous System Lymphoma (PCNSL). This study develops methylation‐specific primers, demonstrating their power to distinguish PCNSL from other CNS diseases via a novel plasma‐based detection method.
Feng Yan, Yaming Wang, Xiaotong Fan, Penghu Wei, Yongzhi Shan   +4 more
wiley   +1 more source

A glaucoma drainage implant functioning as a sanctuary site for vitreoretinal lymphoma

American Journal of Ophthalmology Case Reports
Purpose: To report an unusual case of vitreoretinal lymphoma (VRL) in which a glaucoma drainage implant (GDI) likely functioned as a sanctuary site for relapsing disease. Observations: A 54-year-old female with recently diagnosed CNS diffuse large B-cell
Debora H. Lee, Jennifer Li-Wang, Patricia Chevez-Barrios, Amy C. Schefler   +3 more
doaj   +1 more source

Diagnostic procedures in vitreoretinal lymphoma

, 2014
Purpose: To evaluate the type and number of diagnostic interventions needed to confirm the presence of vitreoretinal lymphoma. Method: Chart review of interventions performed for diagnosis of vitreoretinal lymphoma.
Sen, H. Nida, Dalal, Monica, Moriarty, Emily, Faia, Lisa, Casady, Megan, Nussenblatt, Robert, Chan, Chi Chao   +6 more
core   +1 more source

Use of intravitreal rituximab for treatment of vitreoretinal lymphoma [PDF]

, 2015
Aim: Vitreoretinal lymphoma is a diffuse large B cell non-Hodgkin lymphoma. Targeting malignant cells with rituximab is being used increasingly as local chemotherapy, but information on this treatment is scant.
Essex, Rohan, Lake, Stewart, Singh, Arun, Comer, Grant M, Lim, Lyndell L, Merrill, Pauline, Sen, H Nida, Larkin, Kelly L, Saboo, Ujwala S, Forooghian, Farzin, Mackensen, Friederike   +10 more
core   +1 more source

Secondary central nervous system lymphoma (SCNSL) in mantle cell lymphoma (MCL): Characteristics and risk factors in a Danish nationwide population‐based study

British Journal of Haematology, Volume 207, Issue 4, Page 1366-1376, October 2025.
In a nationwide cohort study, 873 patients with mantle cell lymphoma (MCL) were followed for a median of 7 years. During follow‐up, 28 patients developed secondary central nervous system (CNS) lymphoma (SCNSL) with a 5‐year cumulative incidence of 2.8% (95% confidence interval [CI] 1.7–3.9).
Trine Trab, Torgerð Ranadóttir, Iman Chanchiri, Ahmed Ludvigsen Al‐Mashhadi, Emma Berggreen Dall, Stine Rasch, Mette Johansen, Laura Mors Haunstrup, Gabriella Cunsolo, Christian Bjørn Poulsen, Thomas Stauffer Larsen, Simon Husby, Peter Brown, Eliza A. Hawkes, Tarec C. El‐Galaly, Kirsten Grønbæk   +15 more
wiley   +1 more source

In the era of targeted therapy and immunotherapy: advances in the treatment of large B-cell lymphoma of immune-privileged sites

Frontiers in Immunology
Primary large B-cell lymphomas of immune-privileged sites (IP-LBCLs) include primary central nervous system large B-cell lymphoma (PCNSL), primary vitreoretinal large B-cell lymphoma (PVRL), and primary testicular large B-cell lymphoma (PTL).
Haotian Wang, Ying Zhang, Xin Wan, Zhaoxia Li, Ou Bai   +4 more
doaj   +1 more source